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Journal Articles Gene Year : 2011

Comparative genomic analysis of dinucleotide repeats in Tritryps.

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Abstract

The protozoans Trypanosoma cruzi, Trypanosoma brucei and Leishmania major (Tritryps), are evolutionarily ancient eukaryotes which cause worldwide human parasitosis. They present unique biological features. Indeed, canonical DNA/RNA cis-acting elements remain mostly elusive. Repetitive sequences, originally considered as selfish DNA, have been lately recognized as potentially important functional sequence elements in cell biology. In particular, the dinucleotide patterns have been related to genome compartmentalization, gene evolution and gene expression regulation. Thus, we perform a comparative analysis of the occurrence, length and location of dinucleotide repeats (DRs) in the Tritryp genomes and their putative associations with known biological processes. We observe that most types of DRs are more abundant than would be expected by chance. Complementary DRs usually display asymmetrical strand distribution, favoring TT and GT repeats in the coding strands. In addition, we find that GT repeats are among the longest DRs in the three genomes. We also show that specific DRs are non-uniformly distributed along the polycistronic unit, decreasing toward its boundaries. Distinctive non-uniform density patterns were also found in the intergenic regions, with predominance at the vicinity of the ORFs. These findings further support that DRs may control genome structure and gene expression.

Dates and versions

pasteur-00686301 , version 1 (09-04-2012)

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María Ana Duhagon, Pablo Smircich, Diego Forteza, Hugo Naya, Noreen Williams, et al.. Comparative genomic analysis of dinucleotide repeats in Tritryps.. Gene, 2011, 487 (1), pp.29-37. ⟨10.1016/j.gene.2011.07.022⟩. ⟨pasteur-00686301⟩
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