Impact of immigration on the molecular epidemiology of tuberculosis in Rhode Island.

Abstract : While foreign-born persons constitute only 11% of the population in the state of Rhode Island, they account for more than 65% of incident tuberculosis (TB) annually. We investigated the molecular-epidemiological differences between foreign-born and U.S.-born TB patients to estimate the degree of recent transmission and identify predictors of clustering. A total of 288 isolates collected from culture-confirmed TB cases in Rhode Island between 1995 and 2004 were fingerprinted by spoligotyping and 12-locus mycobacterial interspersed repetitive units. Of the 288 fingerprinted isolates, 109 (37.8%) belonged to 36 genetic clusters. Our findings demonstrate that U.S.-born patients, Hispanics, Asian/Pacific islanders, and uninsured patients were significantly more likely to be clustered. Recent transmission among the foreign-born population was restricted and occurred mostly locally, within populations originating from the same region. Nevertheless, TB transmission between the foreign-born and U.S.-born population should not be neglected, since 80% of the mixed clusters of foreign- and U.S.-born persons arose from a foreign-born source case. We conclude that timely access to routine screening and treatment for latent TB infection for immigrants is vital for disease elimination in Rhode Island.
Document type :
Journal articles
Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-00691765
Contributor : Nalin Rastogi <>
Submitted on : Friday, April 27, 2012 - 12:27:45 AM
Last modification on : Thursday, February 21, 2019 - 2:30:03 PM

Links full text

Identifiers

Citation

Jessica Vanhomwegen, Awewura Kwara, Melissa Martin, Fizza S Gillani, Arnaud Fontanet, et al.. Impact of immigration on the molecular epidemiology of tuberculosis in Rhode Island.. Journal of Clinical Microbiology, American Society for Microbiology, 2011, 49 (3), pp.834-44. ⟨10.1128/JCM.01952-10⟩. ⟨pasteur-00691765⟩

Share

Metrics

Record views

108