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First case of multidrug-resistant tuberculosis caused by a rare "Beijing-like" genotype of Mycobacterium tuberculosis in Bogotá, Colombia.

Abstract : This report describes a first case due to a genetically distinct and relatively rare "Beijing-like" strain of Mycobacterium tuberculosis isolated from a 15 years old female patient who died shortly after the initiation of antituberculous therapy with second-line drugs. Positive cultures obtained from lung, kidney and adrenal glands upon autopsy were identified as Mycobacterium tuberculosis complex characterized by an identical 15-banded IS6110-RFLP pattern, and were found to be resistant to all the 4 first-line antituberculous drugs tested (rifampin, isoniazid, ethambutol and streptomycin). Spoligotyping followed by comparison with the SITVIT2 database revealed that the isolate belonged to a rare pattern identified as Spoligotype International Type SIT190, which represents only 1.7% of all the Beijing strains worldwide. We present data on its worldwide distribution and present an evolutionary scenario based on available MIRU typing data.
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https://hal-riip.archives-ouvertes.fr/pasteur-00694580
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Submitted on : Friday, May 4, 2012 - 6:25:41 PM
Last modification on : Tuesday, February 12, 2019 - 4:10:06 PM

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Martha I Murcia, Marina Manotas, Yesica J Jiménez, Johana Hernández, Maria Irene Cerezo Cortès, et al.. First case of multidrug-resistant tuberculosis caused by a rare "Beijing-like" genotype of Mycobacterium tuberculosis in Bogotá, Colombia.. Infection, Genetics and Evolution, Elsevier, 2010, 10 (5), pp.678-81. ⟨10.1016/j.meegid.2010.03.010⟩. ⟨pasteur-00694580⟩

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