Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype.

Igor Mokrousov; Violeta Valcheva; Nurmira Sovhozova; Almaz Aldashev; Nalin Rastogi; Jainagul Isakova

Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype.

Igor Mokrousov ^{1, 2, *} Violeta Valcheva ^{1, 3} Nurmira Sovhozova ⁴ Almaz Aldashev ⁴ Nalin Rastogi ¹ Jainagul Isakova ^{4, *}

* Corresponding author

1 Institut Pasteur de la Guadeloupe

2 Institut Pasteur de Saint-Pétersbourg

3 Institut Stephan Angeloff

4 Institute of Molecular Biology and Medicine

Abstract : Here, we present results of the first study of the Mycobacterium tuberculosis genotypes circulating in Kyrgyzstan. We focused on the incarcerated population known to be at high-risk for tuberculosis (TB) and with a significant impact on TB incidence in the general population. Beijing genotype was detected in 42 of 56 M. tuberculosis sputum-extracted DNA samples from newly-diagnosed adult pulmonary TB patients. RIF and INH resistance was genotypically detected in 28% and 55% samples; 13 of 15 MDR strains belonged to Beijing genotype. 12-locus MIRU-VNTR typing showed 8 of 56 samples to be mixed cases; 7 of them contained a Beijing strain. MIRU analysis demonstrated a high homogeneity of the studied collection (HGI=0.66) while 28 of 56 strains had a profile 223325153533 corresponding to Beijing/M2 subtype highly prevalent in different Russian settings. Three hypervariable loci, QUB-3232, VNTR-3820 and VNTR-4120, permitted to further subdivide 28 Beijing/M2 strains into 11 subtypes shared by 1 to 9 strains. To conclude, all markers taken together, the penitentiary population of M. tuberculosis in Kyrgyzstan exhibited a strong genetic affinity to Russia and a weak relatedness to East Asia.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Bacteriology

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https://hal-riip.archives-ouvertes.fr/pasteur-00694590
Contributor : Nalin Rastogi <>
Submitted on : Friday, May 4, 2012 - 6:58:14 PM
Last modification on : Tuesday, February 12, 2019 - 4:10:06 PM

Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype.

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Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype.

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