Bats host major mammalian paramyxoviruses.

Jan Felix Drexler 1 Victor Max Corman 1 Marcel Alexander Müller 1 Gael Darren Maganga 2 Peter Vallo 3 Tabea Binger 1 Florian Gloza-Rausch 1, 4 Andrea Rasche 5 Stoian Yordanov 6 Antje Seebens 4 Samuel Oppong 7 Yaw Adu Sarkodie 7 Célestin Pongombo 8 Alexander N Lukashev 9 Jonas Schmidt-Chanasit 10 Andreas Stöcker 11 Aroldo José Borges Carneiro 12 Stephanie Erbar 13 Andrea Maisner 13 Florian Fronhoffs 14 Reinhard Buettner 14, 15 Elisabeth K V Kalko 16, 17 Thomas Kruppa 18 Carlos Roberto Franke 12 René Kallies 1 Emmanuel R N Yandoko 19 Georg Herrler 5 Chantal Reusken 20 Alexandre Hassanin 21 Detlev H Krüger 22 Sonja Matthee 23 Rainer G Ulrich 24 Eric M Leroy 2, 25 Christian Drosten 1, *
Abstract : The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data.
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Jan Felix Drexler, Victor Max Corman, Marcel Alexander Müller, Gael Darren Maganga, Peter Vallo, et al.. Bats host major mammalian paramyxoviruses.. Nature Communications, Nature Publishing Group, 2012, 3, pp.796. ⟨10.1038/ncomms1796⟩. ⟨pasteur-00700110⟩

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