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Journal articles
Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration
Abstract : We analyzed the virus shedding of an oseltamivir-treated patient who had been infected with the pandemic swine-origin influenza A (H1N1) virus which had an oseltamivir-sensitive neuraminidase. The virus was isolated from the pharyngeal swabs of the patient using MDCK cells, and the virus genome RNA was detected in the same samples both by real-time RT-PCR and RTPCR. The virus was isolated until 44 h after oseltamivir administration although the virus genome was detected until one day after oseltamivir treatment was stopped. Due to their high sensitivity, RT-PCR and real-time RT-PCR may cause misdiagnosis by detection of viral genome which does not infect, and classical virus isolation and clinical symptoms are recommended for the evaluation of oseltamivir treatment.
Cited literature [9 references]
https://hal-riip.archives-ouvertes.fr/pasteur-00702553
Contributor : Marie Bastard <>
Submitted on : Wednesday, May 30, 2012 - 3:50:23 PM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM
Long-term archiving on: : Friday, August 31, 2012 - 2:25:10 AM
Contributor : Marie Bastard <>
Submitted on : Wednesday, May 30, 2012 - 3:50:23 PM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM
Long-term archiving on: : Friday, August 31, 2012 - 2:25:10 AM
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