Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration

Abstract : We analyzed the virus shedding of an oseltamivir-treated patient who had been infected with the pandemic swine-origin influenza A (H1N1) virus which had an oseltamivir-sensitive neuraminidase. The virus was isolated from the pharyngeal swabs of the patient using MDCK cells, and the virus genome RNA was detected in the same samples both by real-time RT-PCR and RTPCR. The virus was isolated until 44 h after oseltamivir administration although the virus genome was detected until one day after oseltamivir treatment was stopped. Due to their high sensitivity, RT-PCR and real-time RT-PCR may cause misdiagnosis by detection of viral genome which does not infect, and classical virus isolation and clinical symptoms are recommended for the evaluation of oseltamivir treatment.
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Leiyun Weng, Qiang Wang, Wei Wang, Peijun Ren, Vincent Deubel, et al.. Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration. Influenza Research and Treatment, Hindawi Publishing Corporation, 2010, 2010 (ID 976084), 3 p. ⟨10.1155/2010/976084⟩. ⟨pasteur-00702553⟩

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