Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration

Leiyun Weng; Qiang Wang; Wei Wang; Peijun Ren; Vincent Deubel; Tetsuya Toyoda

Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration

Leiyun Weng ¹ Qiang Wang ¹ Wei Wang ¹ Peijun Ren ¹ Vincent Deubel ^{1, 2} Tetsuya Toyoda ^{1, 3, 4, *}

* Corresponding author

1 IPS-CAS - Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences

2 Institut Pasteur du Cambodge

3 Choju Medical Institute

4 Infectious Disease Regulation Project

Abstract : We analyzed the virus shedding of an oseltamivir-treated patient who had been infected with the pandemic swine-origin influenza A (H1N1) virus which had an oseltamivir-sensitive neuraminidase. The virus was isolated from the pharyngeal swabs of the patient using MDCK cells, and the virus genome RNA was detected in the same samples both by real-time RT-PCR and RTPCR. The virus was isolated until 44 h after oseltamivir administration although the virus genome was detected until one day after oseltamivir treatment was stopped. Due to their high sensitivity, RT-PCR and real-time RT-PCR may cause misdiagnosis by detection of viral genome which does not infect, and classical virus isolation and clinical symptoms are recommended for the evaluation of oseltamivir treatment.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Virology

Complete list of metadatas

Cited literature [9 references] Display Hide Download

https://hal-riip.archives-ouvertes.fr/pasteur-00702553
Contributor : Marie Bastard <>
Submitted on : Wednesday, May 30, 2012 - 3:50:23 PM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM
Long-term archiving on : Friday, August 31, 2012 - 2:25:10 AM

Shedding_of_the_Pandemic_Swine...

Publisher files allowed on an open archive

Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration

File

Identifiers

Collections

Citation

Export

Metrics

174

211

Contact

Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration

File

Identifiers

Collections

Citation

Export

Share

Metrics

174

211

Contact