Multiple independent introductions of Plasmodium falciparum in South America.

Erhan Yalcindag; Eric Elguero; Céline Arnathau; Durand Patrick; Jean Akiana; Timothy J Anderson; Agnès Aubouy; François Balloux; Patrick Besnard; Hervé Bogreau; Pierre Carnevale; Umberto d'Alessandro; Didier Fontenille; Dionicia Gamboa; Thibaut Jombart; Jacques Le Mire; Eric Leroy; Amanda Maestre; Mayfong Mayxay; Didier Ménard; Lise Musset; Paul N Newton; Dieudonné Nkoghé; Oscar Noya; Benjamin Ollomo; Christophe Rogier; Vincent Veron; Albina Wide; Sedigheh Zakeri; Bernard Carme; Eric Legrand; Christine Chevillon; Francisco J Ayala; François Renaud; Franck Prugnolle

doi:10.1073/pnas.1119058109

Journal articles

Multiple independent introductions of Plasmodium falciparum in South America.

Erhan Yalcindag ^{1, *} Eric Elguero ^{1, *} Céline Arnathau ² Durand Patrick ² Jean Akiana ³ Timothy J Anderson ⁴ Agnès Aubouy ⁵ François Balloux ⁶ Patrick Besnard ⁷ Hervé Bogreau ⁸ Pierre Carnevale ⁹ Umberto d'Alessandro ¹⁰ Didier Fontenille ¹ Dionicia Gamboa ¹¹ Thibaut Jombart ⁶ Jacques Le Mire ⁷ Eric Leroy ^{12, 13, 14} Amanda Maestre ¹⁵ Mayfong Mayxay ¹⁶ Didier Ménard ¹⁷ Lise Musset ¹⁸ Paul N Newton ¹⁶ Dieudonné Nkoghé ^{13, 14} Oscar Noya ^{19, 20} Benjamin Ollomo ^{13, 14} Christophe Rogier ⁸ Vincent Veron ²¹ Albina Wide ^{19, 20} Sedigheh Zakeri ²² Bernard Carme ²¹ Eric Legrand ¹⁸ Christine Chevillon ²³ Francisco J Ayala ^{24, *} François Renaud ^{1, *} Franck Prugnolle ^{1, *}

* Corresponding author

1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle

2 MIVEGEC-HEAT - Health, Emergence, Adaptation and Transmission

PEEC - Processus Écologiques et Évolutifs au sein des Communautés

3 Service Epidémiologie Moléculaire et Parasitaire

4 Department of Genetics

5 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement

6 Medical Research Council Centre for Outbreak Analysis and Modelling

7 Malaria Control Program

8 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes

9 IRD [France-Sud] - Institut de Recherche pour le Développement

10 Department of Parasitology

11 IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"

12 MIVEGEC-VIROZ - Zoonoses virales et MTN

EDIFICE - Biologie des infections virales: Emergence, DIFfusion, Impact, Contrôle, Elimination

13 CIRMF - Centre International de Recherches Médicales de Franceville

14 EPV - Emergence des Pathologies Virales

15 Grupo Salud y Comunidad

16 Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration

17 Institut Pasteur du Cambodge

18 Institut Pasteur de la Guyane

19 Centro para Estudios Sobre Malaria [Venezuela]

20 IMT - Instituto de Medicina Tropical [Caracas, Venezuela}

21 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane

22 Institut Pasteur d'Iran

23 MIVEGEC-EVCO - Evolution of host-microbe communities

PEEC - Processus Écologiques et Évolutifs au sein des Communautés

24 Department of Ecology and Evolutionary Biology

Abstract : The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Parasitology

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Submitted on : Thursday, June 7, 2012 - 7:50:40 PM
Last modification on : Tuesday, May 4, 2021 - 3:23:32 PM

Multiple independent introductions of Plasmodium falciparum in South America.

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Multiple independent introductions of Plasmodium falciparum in South America.

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