Multiple independent introductions of Plasmodium falciparum in South America.

Erhan Yalcindag; Eric Elguero; Céline Arnathau; Patrick Durand; Jean Akiana; Timothy J Anderson; Agnes Aubouy; François Balloux; Patrick Besnard; Hervé Bogreau; Pierre Carnevale; Umberto d'Alessandro; Didier Fontenille; Dionicia Gamboa; Thibaut Jombart; Jacques Le Mire; Eric Leroy; Amanda Maestre; Mayfong Mayxay; Didier Ménard; Lise Musset; Paul N Newton; Dieudonné Nkoghé; Oscar Noya; Benjamin Ollomo; Christophe Rogier; Vincent Veron; Albina Wide; Sedigheh Zakeri; Bernard Carme; Eric Legrand; Christine Chevillon; Francisco J Ayala; François Renaud; Franck Prugnolle

Multiple independent introductions of Plasmodium falciparum in South America.

Erhan Yalcindag ^{1, *} Eric Elguero ^{1, *} Céline Arnathau ¹ Patrick Durand ¹ Jean Akiana ² Timothy J Anderson ³ Agnes Aubouy ⁴ François Balloux ⁵ Patrick Besnard ⁶ Hervé Bogreau ⁷ Pierre Carnevale ⁸ Umberto d'Alessandro ⁹ Didier Fontenille ¹ Dionicia Gamboa ¹⁰ Thibaut Jombart ⁵ Jacques Le Mire ⁶ Eric Leroy ^{1, 11, 12} Amanda Maestre ¹³ Mayfong Mayxay ¹⁴ Didier Ménard ¹⁵ Lise Musset ¹⁶ Paul N Newton ¹⁴ Dieudonné Nkoghé ^{11, 12} Oscar Noya ^{17, 18} Benjamin Ollomo ^{11, 12} Christophe Rogier ⁷ Vincent Veron ¹⁹ Albina Wide ^{17, 18} Sedigheh Zakeri ²⁰ Bernard Carme ¹⁹ Eric Legrand ¹⁶ Christine Chevillon ¹ Francisco J Ayala ^{21, *} François Renaud ^{1, *} Franck Prugnolle ^{1, *}

* Corresponding author

1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle

2 Service Epidémiologie Moléculaire et Parasitaire

3 Department of Genetics

4 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement

5 Medical Research Council Centre for Outbreak Analysis and Modelling

6 Malaria Control Program

7 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes

8 IRD [France-Sud] - Institut de Recherche pour le Développement

9 Department of Parasitology

10 IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"

11 Centre International de Recherche médicale de Franceville

12 EPV - Emergence des Pathologies Virales

13 Grupo Salud y Comunidad

14 Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration

15 Institut Pasteur du Cambodge

16 Institut Pasteur de la Guyane

17 Centro para Estudios Sobre Malaria

18 Instituto de Medicina Tropical

19 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane

20 Institut Pasteur d'Iran

21 Department of Ecology and Evolutionary Biology

Abstract : The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Parasitology

Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-00705564
Contributor : Eric Legrand <>
Submitted on : Thursday, June 7, 2012 - 7:50:40 PM
Last modification on : Tuesday, October 15, 2019 - 2:28:02 PM

Multiple independent introductions of Plasmodium falciparum in South America.

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Multiple independent introductions of Plasmodium falciparum in South America.

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