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Multiple independent introductions of Plasmodium falciparum in South America.

Erhan Yalcindag 1, * Eric Elguero 1, * Céline Arnathau 2 Patrick Durand 2 Jean Akiana 3 Timothy J Anderson 4 Agnes Aubouy 5 François Balloux 6 Patrick Besnard 7 Hervé Bogreau 8 Pierre Carnevale 9 Umberto d'Alessandro 10 Didier Fontenille 1 Dionicia Gamboa 11 Thibaut Jombart 6 Jacques Le Mire 7 Eric Leroy 12, 13, 14 Amanda Maestre 15 Mayfong Mayxay 16 Didier Ménard 17 Lise Musset 18 Paul N Newton 16 Dieudonné Nkoghé 13, 14 Oscar Noya 19, 20 Benjamin Ollomo 13, 14 Christophe Rogier 8 Vincent Veron 21 Albina Wide 19, 20 Sedigheh Zakeri 22 Bernard Carme 21 Eric Legrand 18 Christine Chevillon 23 Francisco J Ayala 24, * François Renaud 1, * Franck Prugnolle 1, *
* Corresponding author
2 MIVEGEC-HEAT - Health, Emergence, Adaptation and Transmission
PEEC - Processus Écologiques et Évolutifs au sein des Communautés
12 MIVEGEC-VIROZ - Zoonoses virales et MTN
EDIFICE - Biologie des infections virales: Emergence, DIFfusion, Impact, Contrôle, Elimination
23 MIVEGEC-EVCO - Evolution of host-microbe communities
PEEC - Processus Écologiques et Évolutifs au sein des Communautés
Abstract : The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.
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Submitted on : Thursday, June 7, 2012 - 7:50:40 PM
Last modification on : Wednesday, October 14, 2020 - 11:00:56 AM

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Erhan Yalcindag, Eric Elguero, Céline Arnathau, Patrick Durand, Jean Akiana, et al.. Multiple independent introductions of Plasmodium falciparum in South America.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2012, 109 (2), pp.511-6. ⟨10.1073/pnas.1119058109⟩. ⟨pasteur-00705564⟩

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