Antiinflammatory Properties of Extracts and Compounds Isolated from Verbascum xanthophoeniceum Griseb.

Petya Dimitrova 1 Emanuela Kostadinova 2 Viktoriya Milanova 1 Kalina Alipieva 2 Milen Georgiev 3 Nina Ivanovska 4, *
* Corresponding author
1 Institut Stephan Angeloff
2 Institute of Organic Chemistry with Centre of Phytochemistry
3 Laboratory of Applied Biotechnologies
Institut Stephan Angeloff, Natural Products Laboratory
4 Department of Immunology
Institut Stephan Angeloff
Abstract : Verbascum xanthophoeniceum Griseb. is an endemic plant of the Balkan region, a representative of the genus Verbascum used in traditional medicine for respiratory and inflammatory disorders. The objective of this study was to evaluate in vivo and in vitro the antiinflammatory action of crude extract, different fractions and pure compounds obtained from V. xanthophoeniceum Griseb. Bioactive metabolites were isolated by the use of low-pressure chromatographic separation. Crude methanol extract (CME) was applied in a model of paw oedema and different fractions and substances were tested in vitro for their effect on NO and cytokine production by peritoneal macrophages, and on the COX-1 and COX-2 expression. The CME exerted inhibition on cobra venom factor (CVF)-induced oedema in mice, in correlation with reduced alternative pathway (AP) complement activity. A highly suppressive effect was expressed by nigroside VI on IL-6 and NO production and by forsythoside B on TNF-α production. Leucosceptoside B lowered NO release and COX-1 expression in macrophages. Verbascum xanthophoeniceum could serve as a promising source of active compounds with antiinflammatory action, particularly in complement-mediated disorders. Copyright © 2012 John Wiley & Sons, Ltd.
Keywords : leucosceptoside B Verbascum xanthophoeniceum COX1/2 cytokines forsythoside leucosceptoside B.
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Journal articles
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Submitted on : Monday, June 18, 2012 - 10:15:30 AM
Last modification on : Monday, October 8, 2018 - 5:44:08 PM

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Petya Dimitrova, Emanuela Kostadinova, Viktoriya Milanova, Kalina Alipieva, Milen Georgiev, et al.. Antiinflammatory Properties of Extracts and Compounds Isolated from Verbascum xanthophoeniceum Griseb.. Phytotherapy Research, Wiley, 2012, epub ahead of print. ⟨10.1002/ptr.4641⟩. ⟨pasteur-00709185⟩

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