Three-dimensional analysis of combination effect of ellagitannins and acyclovir on herpes simplex virus types 1 and 2.

N. Vilhelmova 1 R. Jacquet 2 S. Quideau 2 A. Stoyanova 1 A. S. Galabov 1, *
* Corresponding author
1 Institut Stephan Angeloff
2 ISM - Institut des Sciences Moléculaires
Abstract : The effects of combinations of three nonahydroxyterphenoyl-bearing C-glucosidic ellagitannins (castalagin, vescalagin and grandinin) with acyclovir (ACV) on the replication of type-1 and type-2 herpes simplex viruses in MDBK cells were tested by the focus-forming units reduction test. Ellagitannins included in these combinations possess a high individual antiviral activity: selectivity index of castalagin and vescalagin versus HSV-1 was similar to that of ACV, and relatively lower against HSV-2. The three-dimensional analytical approach of Prichard and Shipman was used to evaluate the impact of drug-drug interactions. The combination effects of ellagitannins with acyclovir were markedly synergistic.
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Journal articles
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Submitted on : Tuesday, June 26, 2012 - 2:04:11 PM
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N. Vilhelmova, R. Jacquet, S. Quideau, A. Stoyanova, A. S. Galabov. Three-dimensional analysis of combination effect of ellagitannins and acyclovir on herpes simplex virus types 1 and 2.. Antiviral Research, Elsevier Masson, 2011, 89 (2), pp.174-81. ⟨10.1016/j.antiviral.2010.11.014⟩. ⟨pasteur-00712093⟩

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