Challenges associated with curcumin therapy in Alzheimer disease. - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue Expert Reviews in Molecular Medicine Année : 2011

Challenges associated with curcumin therapy in Alzheimer disease.

Résumé

Curcumin, the phytochemical agent in the spice turmeric, which gives Indian curry its yellow colour, is also a traditional Indian medicine. It has been used for millennia as a wound-healing agent and for treating a variety of ailments. The antioxidant, anti-inflammatory, antiproliferative and other properties of curcumin have only recently gained the attention of modern pharmacology. The mechanism of action of curcumin is complex and multifaceted. In part, curcumin acts by activating various cytoprotective proteins that are components of the phase II response. Over the past decade, research with curcumin has increased significantly. In vitro and in vivo studies have demonstrated that curcumin could target pathways involved in the pathophysiology of Alzheimer disease (AD), such as the β-amyloid cascade, tau phosphorylation, neuroinflammation or oxidative stress. These findings suggest that curcumin might be a promising compound for the development of AD therapy. However, its insolubility in water and poor bioavailability have limited clinical trials and its therapeutic applications. To be effective as a drug therapy, curcumin must be combined with other drugs, or new delivery strategies need to be developed.
Fichier non déposé

Dates et versions

pasteur-00722943 , version 1 (06-08-2012)

Identifiants

Citer

Abdenour Belkacemi, Sihem Doggui, Lé Dao, Charles Ramassamy. Challenges associated with curcumin therapy in Alzheimer disease.. Expert Reviews in Molecular Medicine, 2011, 13, pp.e34. ⟨10.1017/S1462399411002055⟩. ⟨pasteur-00722943⟩

Collections

RIIP INRS-IAF
49 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More