Bidirectional interactions between bone metabolism and hematopoiesis.

Geneviève Despars (1) , Yves St-Pierre (2)

1 Département de Pharmacologie
2 INRS-IAF - Institut Armand Frappier

Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.

Domaines: Maladies infectieuses; Hématologie

Geneviève Despars, Yves St-Pierre. Bidirectional interactions between bone metabolism and hematopoiesis.. Experimental Hematology, 2011, 39 (8), pp.809-16. ⟨10.1016/j.exphem.2011.04.008⟩. ⟨pasteur-00723262⟩