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Bidirectional interactions between bone metabolism and hematopoiesis.

Abstract : Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.
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https://hal-riip.archives-ouvertes.fr/pasteur-00723262
Contributor : Nancy Laflamme <>
Submitted on : Wednesday, August 8, 2012 - 4:45:16 PM
Last modification on : Wednesday, April 17, 2019 - 12:21:21 PM

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Geneviève Despars, Yves St-Pierre. Bidirectional interactions between bone metabolism and hematopoiesis.. Experimental Hematology, Elsevier, 2011, 39 (8), pp.809-16. ⟨10.1016/j.exphem.2011.04.008⟩. ⟨pasteur-00723262⟩

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