Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Bidirectional interactions between bone metabolism and hematopoiesis.

Abstract : Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.
Complete list of metadata
Contributor : Nancy Laflamme Connect in order to contact the contributor
Submitted on : Wednesday, August 8, 2012 - 4:45:16 PM
Last modification on : Wednesday, April 17, 2019 - 12:21:21 PM




Geneviève Despars, yves St-Pierre. Bidirectional interactions between bone metabolism and hematopoiesis.. Experimental Hematology, Elsevier, 2011, 39 (8), pp.809-16. ⟨10.1016/j.exphem.2011.04.008⟩. ⟨pasteur-00723262⟩



Record views