Exogenous VIP limits zymosan-induced generalized inflammation (ZIGI) in mice.

Nina Ivanovska (1) , Reni Kalfin (2) , Maria Lazarova (2) , Petya Dimitrova (1)

1 Institut Stephan Angeloff
2 Laboratory of Neuropeptides

Vasoactive intestinal peptide (VIP) was administered in a model of zymosan-induced generalized inflammation (ZIGI). Its beneficial action was associated with reduced TNF-alpha and increased IL-10 production, lowered levels of creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin in circulation. VIP diminished the level of RANTES and MIP-1alpha in peritoneal exudate and circulation. The neuropeptide inhibited NO release from stimulated peritoneal macrophages. Decreased spleen, liver and kidney enlargement and less pathological changes in liver were observed. The effect of VIP was attenuated by pretreatment with VIP antagonist (anti-VIP) before the induction of shock.

Domains: Immunology

Nina Ivanovska, Reni Kalfin, Maria Lazarova, Petya Dimitrova. Exogenous VIP limits zymosan-induced generalized inflammation (ZIGI) in mice.. Immunology Letters, 2007, 110 (2), pp.126-32. ⟨10.1016/j.imlet.2007.04.003⟩. ⟨pasteur-00724513⟩