S. Bellon, M. J. Fitzgibbon, T. Fox, H. M. Hsiao, W. et al., The structure of phosphorylated P38?? is monomeric and reveals a conserved activation-loop conformation, Structure, vol.7, issue.9, pp.1057-1065, 1999.
DOI : 10.1016/S0969-2126(99)80173-7

F. Bengs, A. Scholz, D. Kuhn, and M. Wiese, LmxMPK9, a mitogen-activated protein kinase homologue affects flagellar length in Leishmania mexicana, Molecular Microbiology, vol.277, issue.5, pp.1606-1615, 2005.
DOI : 10.1111/j.1365-2958.2005.04498.x

P. Bhattacharya, G. Gupta, S. Majumder, A. Adhikari, S. Banerjee et al., Arabinosylated Lipoarabinomannan Skews Th2 Phenotype towards Th1 during Leishmania Infection by Chromatin Modification: Involvement of MAPK Signaling, PLoS ONE, vol.162, issue.5, 2011.
DOI : 10.1371/journal.pone.0024141.t001

M. J. Brumlik, S. Pandeswara, S. M. Ludwig, K. Murthy, and T. J. Curiel, Parasite Mitogen-Activated Protein Kinases as Drug Discovery Targets to Treat Human Protozoan Pathogens, Journal of Signal Transduction, vol.174, issue.7, p.971968, 2011.
DOI : 10.1038/nchembio837

G. Chen, M. D. Porter, J. R. Bristol, M. J. Fitzgibbon, and S. Pazhanisamy, Kinetic Mechanism of the p38-?? MAP Kinase:?? Phosphoryl Transfer to Synthetic Peptides, Biochemistry, vol.39, issue.8, pp.2079-2087, 2000.
DOI : 10.1021/bi9919495

D. Chuderland, A. Konson, and R. Seger, Identification and Characterization of a General Nuclear Translocation Signal in Signaling Proteins, Molecular Cell, vol.31, issue.6, pp.850-861, 2008.
DOI : 10.1016/j.molcel.2008.08.007

W. L. Delano, The PyMOL Molecular Graphics System DeLano Scientific, 2002.

P. Emsley and K. Cowtan, : model-building tools for molecular graphics, Acta Crystallographica Section D Biological Crystallography, vol.60, issue.12, pp.2126-2132, 2004.
DOI : 10.1107/S0907444904019158

M. Huse and J. Kuriyan, The Conformational Plasticity of Protein Kinases, Cell, vol.109, issue.3, pp.275-282, 2002.
DOI : 10.1016/S0092-8674(02)00741-9

L. N. Johnson, Protein kinase inhibitors: contributions from structure to clinical compounds, Quarterly Reviews of Biophysics, vol.1784, issue.01, pp.1-40, 2009.
DOI : 10.1016/j.tips.2008.02.005

N. Kannan, A. F. Neuwald, . Mapk, . Cdk, . Gsk et al., Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2??, Protein Science, vol.56, issue.8, pp.2059-2077, 2004.
DOI : 10.1110/ps.04637904

N. Kannan, S. S. Taylor, Y. Zhai, J. C. Venter, and G. Manning, Structural and Functional Diversity of the Microbial Kinome, PLoS Biology, vol.109, issue.3, p.17, 2007.
DOI : 10.1371/journal.pbio.0050017.sd003

A. P. Kornev, N. M. Haste, S. S. Taylor, and L. F. Eyck, Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism, Proc. Natl. Acad. Sci. USA 103, pp.17783-17788, 2006.
DOI : 10.1073/pnas.0607656103

S. Kramer, Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastids, Molecular and Biochemical Parasitology, vol.181, issue.2, pp.61-72, 2012.
DOI : 10.1016/j.molbiopara.2011.10.002

S. Kumari, S. Singh, B. Saha, and P. K. Paliwal, Leishmania major MAP kinase 10 is protective against experimental L. major infection, Vaccine, vol.29, issue.48, pp.8783-8787, 2011.
DOI : 10.1016/j.vaccine.2011.04.030

M. A. Morales, R. Watanabe, C. Laurent, P. Lenormand, J. C. Rousselle et al., Phosphoproteomic analysis ofLeishmania donovani pro- and amastigote stages, PROTEOMICS, vol.38, issue.2, pp.350-363, 2008.
DOI : 10.1002/pmic.200700697

C. Naula, M. Parsons, and J. C. Mottram, Protein kinases as drug targets in trypanosomes and Leishmania, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1754, issue.1-2, pp.151-159, 2005.
DOI : 10.1016/j.bbapap.2005.08.018

H. Neuber, Leishmaniasis, Journal der Deutschen Dermatologischen Gesellschaft, vol.6, issue.9, pp.754-765, 2008.
DOI : 10.1111/j.1610-0387.2008.06809.x

K. K. Ojo, T. L. Arakaki, A. J. Napuli, K. K. Inampudi, K. R. Keyloun et al., Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure???activity relationships with Trypanosoma brucei GSK-3, Molecular and Biochemical Parasitology, vol.176, issue.2, pp.98-108, 2011.
DOI : 10.1016/j.molbiopara.2010.12.009

C. Pargellis, L. Tong, L. Churchill, P. F. Cirillo, T. Gilmore et al., Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site, Nature Structural Biology, vol.9, issue.4, pp.268-272, 2002.
DOI : 10.1038/nsb770

A. Plotnikov, D. Chuderland, Y. Karamansha, O. Livnah, and R. Seger, Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation, Molecular and Cellular Biology, vol.31, issue.17, pp.3515-3530, 2011.
DOI : 10.1128/MCB.05424-11

A. Plotnikov, E. Zehorai, S. Procaccia, and R. Seger, The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1813, issue.9, pp.1619-1633, 2011.
DOI : 10.1016/j.bbamcr.2010.12.012

. Horjales, The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms, Please cite this article in press as, 2012.
DOI : 10.1016/j.str.2012.07.005

URL : https://hal.archives-ouvertes.fr/pasteur-00727033

B. Rotureau, M. A. Morales, P. Bastin, and G. F. Spä-th, The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?, Cellular Microbiology, vol.48, issue.5, pp.710-718, 2009.
DOI : 10.1111/j.1462-5822.2009.01295.x

E. D. Scheeff and P. E. Bourne, Structural Evolution of the Protein Kinase???Like Superfamily, PLoS Computational Biology, vol.31, issue.5, p.49, 2005.
DOI : 10.1371/journal.pcbi.0010049.sg002

T. Schindler, W. Bornmann, P. Pellicena, W. T. Miller, B. Clarkson et al., Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase, Science, vol.289, issue.5486, 1938.
DOI : 10.1126/science.289.5486.1938

J. R. Simard, M. Getlik, C. Grü-tter, V. Pawar, S. Wulfert et al., Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors, Journal of the American Chemical Society, vol.131, issue.37, 2009.
DOI : 10.1021/ja902010p

S. S. Taylor and E. Radzio-andzelm, Three protein kinase structures define a common motif, Structure, vol.2, issue.5, pp.345-355, 1994.
DOI : 10.1016/S0969-2126(00)00036-8

S. S. Taylor and A. P. Kornev, Protein kinases: evolution of dynamic regulatory proteins, Trends in Biochemical Sciences, vol.36, issue.2, pp.65-77, 2011.
DOI : 10.1016/j.tibs.2010.09.006

P. Thé-venet, Y. Shen, J. Maupetit, F. Guyon, P. Derreumaux et al., PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides, Nucleic Acids Res, pp.40-288, 2012.

S. Trapani and J. Navaza, : classical and modern, Acta Crystallographica Section D Biological Crystallography, vol.64, issue.1, pp.11-16, 2008.
DOI : 10.1107/S0907444907044460

A. G. Turjanski, G. Hummer, G. , and J. S. , How Mitogen-Activated Protein Kinases Recognize and Phosphorylate Their Targets: A QM/MM Study, Journal of the American Chemical Society, vol.131, issue.17, 2009.
DOI : 10.1021/ja8071995

M. Wiese, A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host, The EMBO Journal, vol.17, issue.9, 1998.
DOI : 10.1093/emboj/17.9.2619

M. Wiese, Leishmania MAP kinases ??? Familiar proteins in an unusual context, International Journal for Parasitology, vol.37, issue.10, pp.1053-1062, 2007.
DOI : 10.1016/j.ijpara.2007.04.008

X. Xie, Y. Gu, T. Fox, J. T. Coll, M. A. Fleming et al., Crystal structure of JNK3: a kinase implicated in neuronal apoptosis, Structure, vol.6, issue.8, pp.983-991, 1998.
DOI : 10.1016/S0969-2126(98)00100-2

Z. Yang, X. Zhang, P. A. Darrah, and D. M. Mosser, The Regulation of Th1 Responses by the p38 MAPK, The Journal of Immunology, vol.185, issue.10, pp.6205-6213, 2010.
DOI : 10.4049/jimmunol.1000243

Y. Y. Zhang, Z. Q. Mei, J. W. Wu, and W. , Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38?? in Different Phosphorylation States, Journal of Biological Chemistry, vol.283, issue.39, pp.26591-26601, 2008.
DOI : 10.1074/jbc.M801703200