R. B. Abderrazek, I. Hmila, C. Vincke, Z. Benlasfar, M. Pellis et al., Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom, Biochemical Journal, vol.74, issue.2, pp.263-272, 2009.
DOI : 10.1074/jbc.M806889200

URL : https://hal.archives-ouvertes.fr/pasteur-00859429

F. Abroug, S. El-atrous, S. Nouira, H. Haguiga, N. Touzi et al., Serotherapy in scorpion envenomation: a randomised controlled trial, The Lancet, vol.354, issue.9182, pp.906-909, 1999.
DOI : 10.1016/S0140-6736(98)12083-4

F. Abroug, S. Nouira, S. El-atrous, L. Besbes, R. Boukef et al., A canine study of immunotherapy in scorpion envenomation, Intensive Care Medicine, vol.29, issue.12, pp.2266-2276, 2003.
DOI : 10.1007/s00134-003-1947-0

G. P. Adams, J. E. Mccartney, M. S. Tai, H. Oppermann, J. S. Huston et al., Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv, Cancer Res, vol.53, pp.4026-4034, 1993.

S. Adi-bessalem, D. Hammoudi-triki, and F. Laraba-djebari, Pathophysiological effects of Androctonus australis hector scorpion venom: Tissue damages and inflammatory response, Experimental and Toxicologic Pathology, vol.60, issue.4-5, pp.373-380, 2008.
DOI : 10.1016/j.etp.2008.03.006

I. Burvenich, S. Schoonooghe, B. Cornelissen, P. Blanckaert, E. Coene et al., In vitro and In vivo Targeting Properties of Iodine-123- or Iodine-131-Labeled Monoclonal Antibody 14C5 in a Non-Small Cell Lung Cancer and Colon Carcinoma Model, Clinical Cancer Research, vol.11, issue.20, pp.7288-7296, 2005.
DOI : 10.1158/1078-0432.CCR-04-2503

I. J. Burvenich, S. Schoonooghe, P. Blanckaert, K. Bacher, L. Vervoort et al., Biodistribution and planar gamma camera imaging of 123I- and 131I-labeled F(ab???)2 and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor, Nuclear Medicine and Biology, vol.34, issue.3, pp.257-265, 2007.
DOI : 10.1016/j.nucmedbio.2006.12.006

E. S. Calderon-aranda, G. Rivière, V. Choumet, L. D. Possani, and C. Bon, Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab???)2, Toxicon, vol.37, issue.5, pp.771-782, 1999.
DOI : 10.1016/S0041-0101(98)00216-5

M. M. Corrêa, S. V. Sampaio, R. A. Lopes, L. C. Mancuso, O. A. Cunha et al., Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I, Toxicon, vol.35, issue.7, pp.1053-1067, 1997.
DOI : 10.1016/S0041-0101(96)00219-X

M. M. Correa, S. V. Sampaio, R. A. Lopes, L. C. Mancuso, O. A. Cunha et al., Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I, Toxicon, vol.35, issue.7, pp.1053-1067, 1997.
DOI : 10.1016/S0041-0101(96)00219-X

V. Cortez-retamozo, M. Lauwereys, G. G. Hassanzadeh, M. Gobert, K. Conrath et al., Efficient tumor targeting by single-domain antibody fragments of camels, International Journal of Cancer, vol.78, issue.3, pp.456-462, 2002.
DOI : 10.1002/ijc.10212

V. Cortez-retamozo, N. Backmann, P. D. Senter, U. Wernery, P. De-baetselier et al., Efficient Cancer Therapy with a Nanobody-Based Conjugate, Cancer Research, vol.64, issue.8, pp.2853-2857, 2004.
DOI : 10.1158/0008-5472.CAN-03-3935

P. Cupo and S. E. Hering, Cardiac troponin I release after severe scorpion envenoming by Tityus serrulatus, Toxicon, vol.40, issue.6, pp.823-830, 2002.
DOI : 10.1016/S0041-0101(02)00080-6

P. Cupo, M. Jurca, M. M. Azevedo-marques, J. S. Oliveira, and S. E. Hering, Severe scorpion envenomation in Brazil, Clinical, laboratory and anatomopathological aspects. Rev. Inst. Med. Trop. Sao Paulo, vol.36, pp.67-76, 1994.

H. Daisley, D. Alexander, and P. Miller, Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics, Toxicon, vol.37, issue.1, pp.159-165, 1999.
DOI : 10.1016/S0041-0101(98)00174-3

A. R. De-roodt, N. R. Lago, O. D. Salomón, R. D. Laskowicz, L. E. Neder-de-román et al., A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens, Toxicon, vol.53, issue.1, pp.1-8, 2009.
DOI : 10.1016/j.toxicon.2008.10.003

C. Devaux, B. Jouirou, M. N. Krifi, O. Clot-faybesse, M. Ayeb et al., Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom, Toxicon, vol.43, issue.6, pp.661-669, 2004.
DOI : 10.1016/j.toxicon.2004.02.021

L. Freire-maia, Pharmacology of Tityus serrulatus scorpion venom, Anexos Mem. Inst. Butantan, vol.52, pp.51-57, 1990.

L. Freire-maia and I. M. De-matos, Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion venom in the rat, Toxicon, vol.31, issue.9, pp.1207-1210, 1993.
DOI : 10.1016/0041-0101(93)90137-8

Y. D. Fukuhara, M. L. Reis, R. Dellalibera-joviliano, F. Q. Cunha, and E. A. Donadi, Increased plasma levels of IL-1??, IL-6, IL-8, IL-10 and TNF-?? in patients moderately or severely envenomed by Tityus serrulatus scorpion sting, Toxicon, vol.41, issue.1, pp.49-55, 2003.
DOI : 10.1016/S0041-0101(02)00208-8

L. O. Gainkam, L. Huang, V. Caveliers, M. Keyaerts, S. Hernot et al., Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT, Journal of Nuclear Medicine, vol.49, issue.5, pp.788-795, 2008.
DOI : 10.2967/jnumed.107.048538

L. O. Gainkam, V. Caveliers, N. Devoogdt, C. Vanhove, C. Xavier et al., Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice, Contrast Media & Molecular Imaging, vol.12, issue.2, pp.85-92, 2011.
DOI : 10.1002/cmmi.408

M. Gueron, R. Ilia, and S. Sofer, The cardiovascular system after scorpion envenomation. A Review, Journal of Toxicology: Clinical Toxicology, vol.1, issue.2, pp.245-258, 1992.
DOI : 10.1177/000992288502400303

D. Hammoudi-triki, J. Lefort, C. Rougeot, A. Robbe-vincent, C. Bon et al., Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in rats: Optimization of antivenom therapy, Toxicology and Applied Pharmacology, vol.218, issue.3, pp.205-214, 2007.
DOI : 10.1016/j.taap.2006.11.003

I. Hmila, R. B. Abdallah, D. Saerens, Z. Benlasfar, K. Conrath et al., VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI???, Molecular Immunology, vol.45, issue.14, pp.3847-3856, 2008.
DOI : 10.1016/j.molimm.2008.04.011

URL : https://hal.archives-ouvertes.fr/pasteur-01375223

I. Hmila, D. Saerens, B. Abderrazek, R. Vincke, C. Abidi et al., A bispecific nanobody to provide full protection against lethal scorpion envenoming, The FASEB Journal, vol.24, issue.9, pp.3479-3489, 2010.
DOI : 10.1096/fj.09-148213

URL : https://hal.archives-ouvertes.fr/pasteur-00612182

M. Ismail, The treatment of the scorpion envenoming syndrome: The Saudi experience with serotherapy, Toxicon, vol.32, issue.9, pp.1019-1026, 1994.
DOI : 10.1016/0041-0101(94)90384-0

M. Ismail, The scorpion envenoming syndrome, Toxicon, vol.33, issue.7, pp.825-858, 1995.
DOI : 10.1016/0041-0101(95)00005-7

M. Ismail and M. A. Abd-elsalam, Are the toxicological effects of scorpion envenomation related to tissue venom concentration?, Toxicon, vol.26, issue.3, pp.233-256, 1988.
DOI : 10.1016/0041-0101(88)90215-2

M. Ismail and M. A. Abd-elsalam, Pharmacokinetics of 125I-labelled IgG, F(ab???)2 and Fab fractions of scorpion and snake antivenins: merits and potential for therapeutic use, Toxicon, vol.36, issue.11, pp.1523-1528, 1998.
DOI : 10.1016/S0041-0101(98)00144-5

. Fig, Histological analysis of heart tissues from mice that received physiological serum (A ×40 magnification) or 11 ?g sub lethal dose of AahG50 toxic fraction (B ×40 magnification ); heart tissues from mice that received 26 ?g (2 LD50) of AahG50 toxic fraction (C ×40 magnification); heart tissues from mice that received 26 ?g (2 LD50) of AahG50 toxic fraction (D ×40) and treated with NbF12-10, Df + Cf stands for dissociation and contraction of myocardium fibers

F. Jamal, J. Strotmann, F. Weidemann, T. Kukulski, J. D-'hooge et al., Noninvasive Quantification of the Contractile Reserve of Stunned Myocardium by Ultrasonic Strain Rate and Strain, Circulation, vol.104, issue.9, pp.1059-1065, 2001.
DOI : 10.1161/hc3501.093818

H. Kobayashi, K. Shirakawa, S. Kawamoto, T. Saga, N. Sato et al., Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256) Cancer Res, pp.860-866, 2002.

M. N. Krifi, F. Amri, H. Kharrat, and M. Ayeb, Evaluation of antivenom therapy in children severely envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpions, Toxicon, vol.37, issue.11, pp.1627-1634, 1999.
DOI : 10.1016/S0041-0101(99)00079-3

A. M. Loening and S. S. Gambhir, AMIDE: A Free Software Tool for Multimodality Medical Image Analysis, Molecular Imaging, vol.2, issue.3, pp.131-137, 2003.
DOI : 10.1162/153535003322556877

I. M. Matos, M. M. Teixeira, R. Leite, and L. Freire-maia, Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum, European Journal of Pharmacology, vol.368, issue.2-3, pp.231-236, 1999.
DOI : 10.1016/S0014-2999(99)00016-3

C. A. Mazzei-de-dávila, D. F. Dávila, J. H. Donis, G. Arata-de-bellabarba, V. Villareal et al., Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation, Toxicon, vol.40, issue.9, pp.1339-1346, 2002.
DOI : 10.1016/S0041-0101(02)00145-9

A. R. Meki, Z. M. Mohamed, M. El-deen, and H. M. , Significance of assessment of serum cardiac troponin I and interleukin-8 in scorpion envenomed children, Toxicon, vol.41, issue.2, pp.129-137, 2003.
DOI : 10.1016/S0041-0101(02)00155-1

Y. Miao, N. K. Owen, D. Whitener, F. Gallazzi, T. J. Hoffman et al., In vivo evaluation of188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy, International Journal of Cancer, vol.62, issue.5, pp.480-487, 2002.
DOI : 10.1002/ijc.10640

F. Miranda, C. Kupeyan, C. Rochat, H. Rochat, and S. Lissitzky, Purification of Animal Neurotoxins. Isolation and Characterization of Eleven Neurotoxins from the Venoms of the Scorpions Androctonus australis Hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus, European Journal of Biochemistry, vol.17, issue.3, pp.514-523, 1970.
DOI : 10.1016/0003-2697(60)90045-2

P. Peres, A. C. Nonaka, P. N. De-carvalho, T. Pde, M. H. Toyama et al., Effects of Tityus serrulatus scorpion venom on lung mechanics and inflammation in mice, Toxicon, vol.53, issue.7-8, pp.779-785, 2009.
DOI : 10.1016/j.toxicon.2009.02.002

G. Pavlinkova, G. W. Beresford, B. J. Booth, S. K. Batra, and D. Colcher, Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts, J. Nucl. Med, vol.40, pp.1536-1546, 1999.

V. L. Petricevich, Scorpion venom and the inflammatory response. Mediators Inflammation, 2010.

M. H. Pipelzadeh, A. R. Dezfulian, M. T. Jalali, and A. K. Mansouri, In vitro and in vivo studies on some toxic effects of the venom from Hemiscorpious lepturus scorpion, Toxicon, vol.48, issue.1, pp.93-103, 2006.
DOI : 10.1016/j.toxicon.2006.04.017

L. D. Possani, B. Becerril, M. Delpierre, and J. Tytgat, Scorpion toxins specific for Na+-channels, European Journal of Biochemistry, vol.22, issue.2, pp.287-300, 1999.
DOI : 10.1016/0076-6879(90)83018-5

URL : https://hal.archives-ouvertes.fr/pasteur-00370477

S. Sami-merah, D. Hammoudi-triki, M. F. Martin-eauclaire, and F. Laraba-djebari, Combination of two antibody fragments F(ab???)2/Fab: An alternative for scorpion envenoming treatment, International Immunopharmacology, vol.8, issue.10, pp.1386-1394, 2008.
DOI : 10.1016/j.intimp.2008.05.011

URL : https://hal.archives-ouvertes.fr/hal-00396766

S. Sofer and M. Gueron, Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: Hemodynamic and neurological aspects, Toxicon, vol.26, issue.10, pp.931-939, 1988.
DOI : 10.1016/0041-0101(88)90258-9

M. Sofer, R. M. Gueron, M. White, and R. N. Lifshitz, Interleukin-6 release following scorpion sting in children, Toxicon, vol.34, issue.3, pp.389-392, 1996.
DOI : 10.1016/0041-0101(95)00136-0

A. Tarasiuk, S. Khvatskin, and S. Sofer, Effects of antivenom serotherapy on hemodynamic pathophysiology in dogs injected with L. quinquestriatus scorpion venom, Toxicon, vol.36, issue.7, pp.963-971, 1998.
DOI : 10.1016/S0041-0101(98)00011-7

L. Watson, M. Sheth, R. Denyer, and D. Dostal, Baseline echocardiographic values for adult male rats, Journal of the American Society of Echocardiography, vol.17, issue.2, pp.161-167, 2004.
DOI : 10.1016/j.echo.2003.10.010

C. Weytjens, B. Cosyns, J. D-'hooge, C. Gallez, S. Droogmans et al., Doppler myocardial imaging in adult male rats: Reference values and reproducibility of velocity and deformation parameters, European Journal of Echocardiography, vol.7, issue.6, pp.411-417, 2006.
DOI : 10.1016/j.euje.2006.03.009