The paraphyletic composition of Leishmania donovani zymodeme MON-37 revealed by multilocus microsatellite typing.

Abstract : Multilocus microsatellite typing (MLMT) was employed to compare strains of Leishmania donovani belonging to the MON-37 zymodeme (MON-37 strains) from Cyprus and Israel to MON-37 strains from the Indian subcontinent, the Middle East, China and East Africa as well as strains of other zymodemes. The MLMT data were processed with a distance-based method for construction of phylogenetic trees, factorial correspondence analysis and a Bayesian model-based clustering algorithm. All three approaches assigned the MON-37 strains to different distantly related genetically defined subgroups, corresponding to their geographical origin. Specifically, the Kenyan, Sri Lankan and Indian MON-37 strains were genetically closer to strains of other zymodemes from the same regions than to MON-37 strains from other areas. MON-37 strains from Cyprus and Israel were clearly different not only among themselves, but also compared to all the other MON-37 strains studied and could, therefore, be autochthonous. This study showed that the zymodeme MON-37 is paraphyletic and does not reflect the genetic relationship between strains of different geographical origin.
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https://hal-riip.archives-ouvertes.fr/pasteur-00734694
Contributor : Dionyssios Sgouras <>
Submitted on : Monday, September 24, 2012 - 12:13:51 PM
Last modification on : Friday, August 23, 2019 - 4:16:07 PM

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Mohammad Zahangir Alam, Christos Haralambous, Katrin Kuhls, Evi Gouzelou, Dionyssios N Sgouras, et al.. The paraphyletic composition of Leishmania donovani zymodeme MON-37 revealed by multilocus microsatellite typing.. Microbes and Infection, Elsevier, 2009, 11 (6-7), pp.707-15. ⟨10.1016/j.micinf.2009.04.009⟩. ⟨pasteur-00734694⟩

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