Abstract : Two isochinoline alkaloids, glaucine and oxoglaucine were investigated for their suggested anti-inflammatory influence concerning nitric oxide and cytokine production. Mouse peritoneal macrophages were stimulated with different Toll-like receptor (TLR) ligands such as LPS for TLR4, zymosan for TLR2 and CpG for TLR9. The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands. In regard to IL-12 suppressive effect was registered in the case of CpG stimulation. Glaucine succeeded to enhance LPS and zymosan-induced IL-10 production. The reduction of pro-inflammatory cytokines and increase of anti-inflammatory IL-10 are indicative for their use in different acute and chronic inflammatory diseases.
https://hal-riip.archives-ouvertes.fr/pasteur-00736334 Contributor : Nina IvanovskaConnect in order to contact the contributor Submitted on : Friday, September 28, 2012 - 9:29:35 AM Last modification on : Tuesday, May 3, 2022 - 5:18:01 PM Long-term archiving on: : Friday, December 16, 2016 - 6:20:40 PM