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Journal articles
Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine.
Abstract : Two isochinoline alkaloids, glaucine and oxoglaucine were investigated for their suggested anti-inflammatory influence concerning nitric oxide and cytokine production. Mouse peritoneal macrophages were stimulated with different Toll-like receptor (TLR) ligands such as LPS for TLR4, zymosan for TLR2 and CpG for TLR9. The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands. In regard to IL-12 suppressive effect was registered in the case of CpG stimulation. Glaucine succeeded to enhance LPS and zymosan-induced IL-10 production. The reduction of pro-inflammatory cytokines and increase of anti-inflammatory IL-10 are indicative for their use in different acute and chronic inflammatory diseases.
Cited literature [18 references]
https://hal-riip.archives-ouvertes.fr/pasteur-00736334
Contributor : Nina Ivanovska Connect in order to contact the contributor
Submitted on : Friday, September 28, 2012 - 9:29:35 AM
Last modification on : Thursday, April 4, 2019 - 11:48:11 AM
Long-term archiving on: : Friday, December 16, 2016 - 6:20:40 PM
Contributor : Nina Ivanovska Connect in order to contact the contributor
Submitted on : Friday, September 28, 2012 - 9:29:35 AM
Last modification on : Thursday, April 4, 2019 - 11:48:11 AM
Long-term archiving on: : Friday, December 16, 2016 - 6:20:40 PM
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