Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell line.

Abstract : Ciguatoxins, potent marine neurotoxins responsible for ciguatera, exert their numerous damaging effects through primary binding to the voltage-sensitive sodium channels of excitable cells. Using RAW 264.7 murine macrophages, we report the first experimental study presenting evidence that P-CTX-1B (the most potent congener from the Pacific) could modulate mRNA expression of pro- and anti-inflammatory cytokines as well as of inducible nitric oxide synthase (iNOS). P-CTX-1B, unlike other less potent marine polyether toxins, P-CTX-3C and PbTx-3, induced the overexpression of interleukin (IL)-1beta, IL-6, IL-10, tumor necrosis factor-alpha and iNOS with different magnitude and kinetic profiles, as compared to bacterial lipopolysaccharide (LPS). Unlike LPS, P-CTX-1B did not modulate IL-11 expression. In this report, we provide new evidence of the P-CTX-1B iNOS- and cytokines-inducing ability and shed new light on host response to potent neurotoxins.
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Submitted on : Sunday, October 28, 2012 - 11:48:16 PM
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Mariko Matsui, Shilpa Kumar-Roine, H. Taiana Darius, Mireille Chinain, Dominique Laurent, et al.. Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell line.. Toxicon, Elsevier, 2010, 56 (5), pp.776-84. ⟨10.1016/j.toxicon.2009.05.039⟩. ⟨pasteur-00746415⟩

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