Annexin C4 in A. fumigatus: a proteomics approach to understand the function.

Vahid Khalaj (1) , Bahareh Azarian (2) , Somayeh Enayati (1) , Behrouz Vaziri (2)

1 Fungal Biotechnology Group, Biotechnology Research Center
2 Protein Chemistry Unit, Biotechnology Research Center

Annexin C4 has been identified as a new member of fungal annexin family. In search of function, we have generated an annexin C4 disruptant strain of human pathogen, Aspergillus fumigatus. Detailed phenotypic analysis confirmed a non essential role of annexin C4 in the growth and sporulation of this pathogen. We applied a comparative proteomics strategy to understand the possible role of this protein in the fungus. The modification of respiratory chain proteins and stress response proteins suggests the occurrence of a mild oxidative stress in anxC4 disruptant strain. This may indicate a possible anti stress function of annexin C4 in A. fumigatus.

Keywords: Annexin C4; A. fumigatus; proteomics; oxidative stress

Domains: Life Sciences [q-bio]; Biotechnology; Computer Science [cs]; Biotechnology

Vahid Khalaj, Bahareh Azarian, Somayeh Enayati, Behrouz Vaziri. Annexin C4 in A. fumigatus: a proteomics approach to understand the function.. Journal of Proteomics, 2011, 74 (10), pp.1950-8. ⟨10.1016/j.jprot.2011.05.018⟩. ⟨pasteur-00746501⟩