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Annexin C4 in A. fumigatus: a proteomics approach to understand the function.

Abstract : Annexin C4 has been identified as a new member of fungal annexin family. In search of function, we have generated an annexin C4 disruptant strain of human pathogen, Aspergillus fumigatus. Detailed phenotypic analysis confirmed a non essential role of annexin C4 in the growth and sporulation of this pathogen. We applied a comparative proteomics strategy to understand the possible role of this protein in the fungus. The modification of respiratory chain proteins and stress response proteins suggests the occurrence of a mild oxidative stress in anxC4 disruptant strain. This may indicate a possible anti stress function of annexin C4 in A. fumigatus.
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Submitted on : Monday, October 29, 2012 - 11:11:43 AM
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Vahid Khalaj, Bahareh Azarian, Somayeh Enayati, Behrouz Vaziri. Annexin C4 in A. fumigatus: a proteomics approach to understand the function.. Journal of Proteomics, Elsevier, 2011, 74 (10), pp.1950-8. ⟨10.1016/j.jprot.2011.05.018⟩. ⟨pasteur-00746501⟩

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