G. L. Ada and P. D. Jones, The Immune Response to Influenza Infection, Curr. Top. Microbiol. Immunol, vol.128, pp.1-54, 1986.
DOI : 10.1007/978-3-642-71272-2_1

G. W. Both, M. J. Sleigh, N. J. Cox, and A. P. Kendal, Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites, J. Virol, vol.48, pp.52-60, 1983.

F. Carrat and A. Flahault, Influenza vaccine: The challenge of antigenic drift, Vaccine, vol.25, issue.39-40, pp.6852-6862, 2007.
DOI : 10.1016/j.vaccine.2007.07.027

P. Chiarella, V. M. Fazio, and E. Signori, Application of Electroporation in DNA Vaccination Protocols, Current Gene Therapy, vol.10, issue.4, pp.281-286, 2010.
DOI : 10.2174/156652310791823506

P. Correale, M. G. Cusi, M. Sabatino, L. Micheli, D. Pozzessere et al., Tumour-associated antigen (TAA)-specific cytotoxic T cell (CTL) response in vitro and in a mouse model, induced by TAA-plasmids delivered by influenza virosomes, European Journal of Cancer, vol.37, issue.16, pp.2097-2103, 2001.
DOI : 10.1016/S0959-8049(01)00241-6

M. G. Cusi, C. Terrosi, G. G. Savellini, D. Genova, G. Zurbriggen et al., Efficient delivery of DNA to dendritic cells mediated by influenza virosomes, Vaccine, vol.22, issue.5-6, pp.735-739, 2004.
DOI : 10.1016/j.vaccine.2003.08.024

T. Daemen, A. De-mare, L. Bungener, J. De-jonge, A. Huckriede et al., Virosomes for antigen and DNA delivery, Advanced Drug Delivery Reviews, vol.57, issue.3, pp.451-463, 2005.
DOI : 10.1016/j.addr.2004.09.005

J. De-jonge, J. M. Leenhouts, M. Holtrop, P. Schoen, P. Scherrer et al., Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA, Biochemical Journal, vol.405, issue.1, pp.41-49, 2007.
DOI : 10.1042/BJ20061756

URL : https://hal.archives-ouvertes.fr/hal-00478703

P. Degano, D. F. Sarphie, and C. R. Bangham, Intradermal DNA immunization of mice against influenza A virus using the novel PowderJectS system, Vaccine, vol.16, issue.4, pp.394-398, 1998.
DOI : 10.1016/S0264-410X(97)00202-8

S. Dokka, D. Toledo, X. Shi, J. Ye, and Y. Rojanasakul, High-efficiency gene transfection of macrophages by lipoplexes, International Journal of Pharmaceutics, vol.206, issue.1-2, pp.97-104, 2000.
DOI : 10.1016/S0378-5173(00)00531-7

J. J. Donnelly, A. Friedman, J. B. Ulmer, and M. A. Liu, Further protection against antigenic drift of influenza virus in a ferret model by DNA vaccination, Vaccine, vol.15, issue.8, pp.865-868, 1997.
DOI : 10.1016/S0264-410X(96)00268-X

J. J. Donnelly, B. Wahren, and M. A. Liu, DNA Vaccines: Progress and Challenges, The Journal of Immunology, vol.175, issue.2, pp.633-639, 2005.
DOI : 10.4049/jimmunol.175.2.633

F. Geeraedts and A. Huckriede, Influenza Vaccines: What Do We Want and How Can We Get It?, Adv. Exp. Med. Biol, vol.780, pp.161-174, 2011.
DOI : 10.1007/978-1-4419-5632-3_13

R. Gluck, C. Moser, and I. C. Metcalfe, Influenza virosomes as an efficient system for adjuvanted vaccine delivery, Expert Opinion on Biological Therapy, vol.62, issue.2, pp.1139-1145, 2004.
DOI : 10.1038/328257a0

C. Herzog, K. Hartmann, V. Kunzi, O. Kursteiner, R. Mischler et al., Eleven years of Inflexal?? V???a virosomal adjuvanted influenza vaccine, Vaccine, vol.27, issue.33, pp.4381-4387, 2009.
DOI : 10.1016/j.vaccine.2009.05.029

M. L. Hillaire, A. D. Osterhaus, and G. F. Rimmelzwaan, Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines, Journal of Biomedicine and Biotechnology, vol.13, issue.1, p.939860, 2011.
DOI : 10.1016/j.vaccine.2006.05.035

D. K. Hong, S. Chang, C. M. Botham, T. D. Giffon, J. Fairman et al., Cationic Lipid/DNA Complex-Adjuvanted Influenza A Virus Vaccination Induces Robust Cross-Protective Immunity, Journal of Virology, vol.84, issue.24, pp.12691-12702, 2010.
DOI : 10.1128/JVI.00769-10

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004296

A. Jamali, F. Sabahi, T. Bamdad, H. Hashemi, F. Mahboudi et al., A DNA Vaccine-Encoded Nucleoprotein of Influenza Virus Fails To Induce Cellular Immune Responses in a Diabetic Mouse Model, Clinical and Vaccine Immunology, vol.17, issue.4, pp.683-687, 2010.
DOI : 10.1128/CVI.00445-09

URL : https://hal.archives-ouvertes.fr/pasteur-00746986

G. S. Jimenez, R. Planchon, Q. Wei, D. Rusalov, A. Geall et al., Vaxfectin???-Formulated Influenza DNA Vaccines Encoding NP and M2 Viral Proteins Protect Mice against Lethal Viral Challenge, Human Vaccines, vol.3, issue.5, pp.157-164, 2007.
DOI : 10.4161/hv.3.5.4175

Y. C. Kim, C. Jarrahian, D. Zehrung, S. Mitragotri, and M. R. Prausnitz, Delivery Systems for Intradermal Vaccination, Curr. Top. Microbiol. Immunol, vol.351, pp.77-112, 2011.
DOI : 10.1007/82_2011_123

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173582

M. A. Liu, DNA vaccines: an historical perspective and view to the future, Immunological Reviews, vol.174, issue.Suppl, pp.62-84, 2011.
DOI : 10.1111/j.1600-065X.2010.00980.x

K. S. Matlin, H. Reggio, A. Helenius, and K. Simons, Infectious entry pathway of influenza virus in a canine kidney cell line, The Journal of Cell Biology, vol.91, issue.3, pp.601-613, 1981.
DOI : 10.1083/jcb.91.3.601

C. Moser, I. C. Metcalfe, and J. F. Viret, Virosomal adjuvanted antigen delivery systems, Expert Review of Vaccines, vol.2, issue.2, pp.189-196, 2003.
DOI : 10.1586/14760584.2.2.189

M. Mutsch, W. Zhou, P. Rhodes, M. Bopp, R. T. Chen et al., Use of the Inactivated Intranasal Influenza Vaccine and the Risk of Bell's Palsy in Switzerland, New England Journal of Medicine, vol.350, issue.9, pp.896-903, 2004.
DOI : 10.1056/NEJMoa030595

K. G. Nicholson, J. M. Wood, and M. Zambon, Influenza, The Lancet, vol.362, issue.9397, pp.1733-1745, 2003.
DOI : 10.1016/S0140-6736(03)14854-4

J. Nordin, J. Mullooly, S. Poblete, R. Strikas, R. Petrucci et al., Influenza Vaccine Effectiveness in Preventing Hospitalizations and Deaths in Persons 65 Years or Older in Minnesota, New York, and Oregon: Data from 3 Health Plans, The Journal of Infectious Diseases, vol.184, issue.6, pp.665-670, 2001.
DOI : 10.1086/323085

P. Palese, Influenza: old and new threats, Nature Medicine, vol.18, issue.12s, pp.82-87, 2004.
DOI : 10.1016/S1286-4579(00)01351-4

F. S. Quan, R. W. Compans, H. H. Nguyen, and S. M. Kang, Induction of Heterosubtypic Immunity to Influenza Virus by Intranasal Immunization, Journal of Virology, vol.82, issue.3, pp.1350-1359, 2008.
DOI : 10.1128/JVI.01615-07

G. F. Rimmelzwaan and A. D. Osterhaus, Influenza vaccines: new developments, Current Opinion in Pharmacology, vol.1, issue.5, pp.491-496, 2001.
DOI : 10.1016/S1471-4892(01)00085-6

P. Schoen, A. Chonn, P. R. Cullis, J. Wilschut, and P. Scherrer, Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesicles, Gene Therapy, vol.6, issue.5, pp.823-832, 1999.
DOI : 10.1038/sj.gt.3300919

Y. A. Smirnov, A. K. Gitelman, E. A. Govorkova, A. S. Lipatov, and N. V. Kaverin, Influenza H5 virus escape mutants: immune protection and antibody production in mice, Virus Research, vol.99, issue.2, pp.205-208, 2004.
DOI : 10.1016/j.virusres.2003.11.012

Z. Stanekova and E. Vareckova, Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development, Virology Journal, vol.7, issue.1, p.351, 2011.
DOI : 10.1186/1743-422X-7-351

T. Stegmann, H. W. Morselt, F. P. Booy, J. F. Van-breemen, G. Scherphof et al., Functional reconstitution of influenza virus envelopes, EMBO J, vol.6, pp.2651-2659, 1987.

K. Stohr, M. P. Kieny, and D. Wood, Influenza pandemic vaccines: how to ensure a low-cost, low-dose option, Nature Reviews Microbiology, vol.4, issue.8, pp.565-566, 2006.
DOI : 10.1038/nrmicro1482

P. Tao, M. Luo, R. Pan, D. Ling, S. Zhou et al., Enhanced protective immunity against H5N1 influenza virus challenge by vaccination with DNA expressing a chimeric hemagglutinin in combination with an MHC class I-restricted epitope of nucleoprotein in mice, Antiviral Research, vol.81, issue.3, pp.253-260, 2009.
DOI : 10.1016/j.antiviral.2008.12.009

J. B. Ulmer, J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner et al., Heterologous protection against influenza by injection of DNA encoding a viral protein, Science, vol.259, issue.5102, pp.1745-1749, 1993.
DOI : 10.1126/science.8456302

J. B. Ulmer, T. M. Fu, R. R. Deck, A. Friedman, L. Guan et al., Protective CD4+ and CD8+ T cells against influenza virus induced by vaccination with nucleoprotein DNA, J. Virol, vol.72, pp.5648-5653, 1998.

R. J. Webby and R. G. Webster, Emergence of influenza A viruses, Philos. Trans. R. Soc. Lond. B Biol. Sci, vol.356, pp.1817-1828, 2001.

W. Yan, W. Chen, and L. Huang, Mechanism of adjuvant activity of cationic liposome: Phosphorylation of a MAP kinase, ERK and induction of chemokines, Molecular Immunology, vol.44, issue.15, pp.3672-3681, 2007.
DOI : 10.1016/j.molimm.2007.04.009

J. J. Yu, C. S. Tripp, and J. H. Russell, Regulation and Phenotype of an Innate Th1 Cell: Role of Cytokines and the p38 Kinase Pathway, The Journal of Immunology, vol.171, issue.11, pp.6112-6118, 2003.
DOI : 10.4049/jimmunol.171.11.6112

E. Zamparo and D. Little, Immunogenicity and effectiveness of virosomal adjuvanted vaccines against influenza: a brief review of their utility in the elderly population, J. Prev. Med. Hyg, vol.52, pp.116-119, 2011.