S. J. Streatfield, Approaches to achieve high-level heterologous protein production in plants, Plant Biotechnology Journal, vol.98, issue.1, pp.2-15, 2007.
DOI : 10.1016/S0958-1669(00)00073-2

H. S. Mason, H. Warzecha, T. Mor, and C. J. And-arntzen, Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine, Trends in Molecular Medicine, vol.8, issue.7, pp.324-329, 2002.
DOI : 10.1016/S1471-4914(02)02360-2

A. S. Karnoup, V. Turkelson, and W. H. Anderson, O-Linked glycosylation in maize-expressed human IgA1, Glycobiology, vol.15, issue.10, pp.965-981, 2005.
DOI : 10.1093/glycob/cwi077

H. Daniell, S. J. Streatfield, and K. Wycoff, Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants, Trends in Plant Science, vol.6, issue.5, pp.219-226, 2001.
DOI : 10.1016/S1360-1385(01)01922-7

J. A. Howard, Commercialization of plant-based vaccines from research and development to manufacturing, Animal Health Research Reviews, vol.1, issue.02, pp.243-245, 2004.
DOI : 10.1023/A:1009622429758

S. J. Streatfield and J. A. Howard, Plant production systems for vaccines, Expert Review of Vaccines, vol.2, issue.6, pp.763-775, 2003.
DOI : 10.1586/14760584.2.6.763

M. E. Villani, B. Morgun, P. Brunetti, C. Marusic, R. Lombardi et al., Plant pharming of a full-sized, tumour-targeting antibody using different expression strategies, Plant Biotechnology Journal, vol.33, issue.1, pp.59-72, 2009.
DOI : 10.1111/j.1467-7652.2008.00371.x

A. Giritch, S. Marillonnet, C. Engler, G. Van-eldik, J. Botterman et al., Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors, Proceedings of the National Academy of Sciences, vol.103, issue.40, pp.14701-14706, 2006.
DOI : 10.1073/pnas.0606631103

P. Circelli, M. Donini, M. E. Villani, E. A. Benvenuto, and C. Marusic, Efficient Agrobacterium-based transient expression system for the production of biopharmaceuticals in plants, Bioengineered Bugs, vol.1, issue.3, pp.221-224, 2010.
DOI : 10.1038/366469a0

S. Werner, O. Breus, Y. Symonenko, S. A. Marillonnet, and Y. Gleba, High-level recombinant protein expression in transgenic plants by using a double-inducible viral vector, Proceedings of the National Academy of Sciences, vol.108, issue.34, 2011.
DOI : 10.1073/pnas.1102928108

A. Giri and M. L. Narasu, Transgenic hairy roots, Biotechnology Advances, vol.18, issue.1, pp.1-22, 2000.
DOI : 10.1016/S0734-9750(99)00016-6

D. Gleba, N. V. Borisjuk, L. G. Borisjuk, R. Kneer, A. Poulev et al., Use of plant roots for phytoremediation and molecular farming, Proceedings of the National Academy of Sciences, vol.96, issue.11, pp.5973-5977, 1999.
DOI : 10.1073/pnas.96.11.5973

R. A. Wongsamuth and P. M. Doran, Production of monoclonal antibodies by tobacco hairy roots, Biotechnology and Bioengineering, vol.52, issue.5, pp.401-415, 1997.
DOI : 10.1002/(SICI)1097-0290(19970605)54:5<401::AID-BIT1>3.0.CO;2-I

R. Franconi, O. C. Demurtas, and S. Massa, Plant-derived vaccines and other therapeutics produced in contained systems, Expert Review of Vaccines, vol.9, issue.8, pp.877-892
DOI : 10.1586/erv.10.91

S. Guillon, J. Tremouillaux-guiller, P. K. Pati, M. A. Rideau, and P. Gantet, Hairy root research: recent scenario and exciting prospects, Current Opinion in Plant Biology, vol.9, issue.3, pp.341-346, 2006.
DOI : 10.1016/j.pbi.2006.03.008

F. A. Medina-bolivar and C. Cramer, Production Of Recombinant Proteins By Hairy Roots Cultured In Ghiasi, 2004.

R. Swanepoel, D. E. Gill, A. J. Shepherd, P. A. Leman, J. H. Mynhardt et al., The Clinical Pathology of Crimean-Congo Hemorrhagic Fever, Clinical Infectious Diseases, vol.11, issue.Supplement 4, pp.794-800, 1989.
DOI : 10.1093/clinids/11.Supplement_4.S794

H. Hoogstraal, Review Article: The Epidemiology of Tick-Borne Crimean-Congo Hemorrhagic Fever in Asia, Europe, and Africa, Journal of Medical Entomology, vol.15, issue.4, pp.307-417, 1979.
DOI : 10.1093/jmedent/15.4.307

A. Papa, B. Ma, S. Kouidou, Q. Tang, C. A. Hang et al., Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China, Emerging Infectious Diseases, vol.8, issue.1, pp.50-53, 2002.
DOI : 10.3201/eid0801.010087

C. A. Whitehouse, Crimean???Congo hemorrhagic fever, Antiviral Research, vol.64, issue.3, pp.145-160, 2004.
DOI : 10.1016/S0166-3542(04)00163-9

A. J. Sanchez, M. J. Vincent, and S. T. Nichol, Characterization of the Glycoproteins of Crimean-Congo Hemorrhagic Fever Virus, Journal of Virology, vol.76, issue.14, pp.7263-7275, 2002.
DOI : 10.1128/JVI.76.14.7263-7275.2002

S. Chinikar, S. M. Ghiasi, R. Hewson, M. A. Moradi, and A. Haeri, Crimean-Congo hemorrhagic fever in Iran and neighboring countries, Journal of Clinical Virology, vol.47, issue.2, 2009.
DOI : 10.1016/j.jcv.2009.10.014

O. Ergonul, Crimean-Congo haemorrhagic fever, The Lancet Infectious Diseases, vol.6, issue.4, pp.203-214, 2006.
DOI : 10.1016/S1473-3099(06)70435-2

A. Bertolotti-ciarlet, J. Smith, K. Strecker, J. Paragas, L. A. Altamura et al., Cellular Localization and Antigenic Characterization of Crimean-Congo Hemorrhagic Fever Virus Glycoproteins, Journal of Virology, vol.79, issue.10, pp.6152-6161, 2005.
DOI : 10.1128/JVI.79.10.6152-6161.2005

B. R. Erickson, V. Deyde, A. J. Sanchez, M. J. Vincent, and S. T. Nichol, N-linked glycosylation of Gn (but not Gc) is important for Crimean Congo hemorrhagic fever virus glycoprotein localization and transport, Virology, vol.361, issue.2, pp.348-355, 2007.
DOI : 10.1016/j.virol.2006.11.023

E. Bergeron, M. J. Vincent, and S. T. Nichol, Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity, Journal of Virology, vol.81, issue.23, pp.13271-13276, 2007.
DOI : 10.1128/JVI.01647-07

L. A. Altamura, A. Bertolotti-ciarlet, J. Teigler, J. Paragas, C. S. Schmaljohn et al., Identification of a Novel C-Terminal Cleavage of Crimean-Congo Hemorrhagic Fever Virus PreGN That Leads to Generation of an NSM Protein, Journal of Virology, vol.81, issue.12, pp.6632-6642, 2007.
DOI : 10.1128/JVI.02730-06

A. A. Ahmed, J. M. Mcfalls, C. Hoffmann, C. M. Filone, S. M. Stewart et al., Presence of broadly reactive and group-specific neutralizing epitopes on newly described isolates of Crimean-Congo hemorrhagic fever virus, Journal of General Virology, vol.86, issue.12, pp.3327-3336, 2005.
DOI : 10.1099/vir.0.81175-0

K. Spik, A. Shurtleff, A. K. Mcelroy, M. C. Guttieri, J. W. Hooper et al., Immunogenicity of combination DNA vaccines for Rift Valley fever virus, tick-borne encephalitis virus, Hantaan virus, and Crimean Congo hemorrhagic fever virus, Vaccine, vol.24, issue.21, pp.4657-4666, 2006.
DOI : 10.1016/j.vaccine.2005.08.034

A. Papa, E. A. Papadimitriou, and I. Christova, The Bulgarian vaccine Crimean-Congo haemorrhagic fever virus strain, Scandinavian Journal of Infectious Diseases, vol.91, issue.3, pp.225-229, 2011.
DOI : 10.3201/eid1506.081567

S. Serke, T. F. Schwarz, H. Baurmann, A. Kirsch, B. Hottentrager et al., Productive infection of in vitro generated haemopoietic progenitor cells from normal human adult peripheral blood with parvovirus B19: studies by morphology, immunocytochemistry, flow-cytometry and DNA-hybridization, British Journal of Haematology, vol.75, issue.1, pp.6-13, 1991.
DOI : 10.1007/BF01739430

W. Wriggers, S. Chakravarty, and P. A. Jennings, Control of protein functional dynamics by peptide linkers, Biopolymers, vol.23, issue.6, pp.736-746, 2005.
DOI : 10.1002/bip.20291

J. F. Topping, Tobacco Transformation, Methods Mol Biol, vol.81, pp.365-372, 1998.
DOI : 10.1385/0-89603-385-6:365

H. Carrer, T. N. Hockenberry, Z. A. Svab, and P. Maliga, Kanamycin resistance as a selectable marker for plastid transformation in tobacco, MGG Molecular & General Genetics, vol.87, issue.1-2, 1993.
DOI : 10.1007/BF00280200

O. Voinnet, S. Rivas, P. A. Mestre, and D. Baulcombe, Retracted: An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus, The Plant Journal, vol.240, issue.5, pp.949-956, 2003.
DOI : 10.1046/j.1365-313X.2003.01676.x

M. W. Lee and Y. Yang, Transient Expression Assay by Agroinfiltration of Leaves, Methods Mol Biol, vol.323, pp.225-229, 2006.
DOI : 10.1385/1-59745-003-0:225

S. L. Dellaporta, J. W. , and J. B. Hicks, A plant DNA minipreparation: Version II, Plant Molecular Biology Reporter, vol.3, issue.4, pp.19-21, 1983.
DOI : 10.1007/BF02712670

J. Sambrook, E. F. , and T. Maniatis, Molecular Cloning: A Laboratory Manual, 2001.

J. Amani, A. H. Salmanian, S. A. Rafati, and S. L. Mousavi, Immunogenic Properties Of Chimeric Protein From Espa, pp.6923-6929, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00789896

S. Haferkamp, L. Fernando, T. F. Schwarz, H. A. Feldmann, and R. Flick, Intracellular Localization Of Crimean-Congo Hemorrhagic Fever (CCHF) Virus Glycoproteins, Virology Journal, vol.2, issue.1, p.42, 2005.
DOI : 10.1186/1743-422X-2-42

M. J. Vincent, A. J. Sanchez, B. R. Erickson, A. Basak, M. Chretien et al., Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Proteolytic Processing by Subtilase SKI-1, Journal of Virology, vol.77, issue.16, pp.8640-8649, 2003.
DOI : 10.1128/JVI.77.16.8640-8649.2003

R. Fischer, E. Stoger, S. Schillberg, P. A. Christou, and R. M. Twyman, Plant-based production of biopharmaceuticals, Current Opinion in Plant Biology, vol.7, issue.2, pp.152-158, 2004.
DOI : 10.1016/j.pbi.2004.01.007

H. Daniell, N. D. Singh, H. A. Mason, and S. J. Streatfield, Plant-made vaccine antigens and biopharmaceuticals, Trends in Plant Science, vol.14, issue.12, pp.669-679, 2009.
DOI : 10.1016/j.tplants.2009.09.009

H. Daniell, G. Ruiz, B. Denes, L. A. Sandberg, and W. Langridge, Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function, BMC Biotechnology, vol.9, issue.1, p.33, 2009.
DOI : 10.1186/1472-6750-9-33

J. Maclean, M. Koekemoer, A. J. Olivier, D. Stewart, . Hitzeroth et al., Optimization of human papillomavirus type 16 (HPV-16) L1 expression in plants: comparison of the suitability of different HPV-16 L1 gene variants and different cell-compartment localization, Journal of General Virology, vol.88, issue.5, pp.1460-1469, 2007.
DOI : 10.1099/vir.0.82718-0

R. Leonard, B. O. Petersen, M. Himly, W. Kaar, N. Wopfner et al., Two Novel Types of O-Glycans on the Mugwort Pollen Allergen Art v 1 and Their Role in Antibody Binding, Journal of Biological Chemistry, vol.280, issue.9, pp.7932-7940, 2005.
DOI : 10.1074/jbc.M410407200

M. Himly, B. Jahn-schmid, A. Dedic, P. Kelemen, N. Wopfner et al., Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain, The FASEB Journal, vol.17, pp.106-108, 2003.
DOI : 10.1096/fj.02-0472fje

M. Laguia-becher, V. Martin, M. Kraemer, M. Corigliano, M. L. Yacono et al., Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice, BMC Biotechnology, vol.10, issue.1, p.52
DOI : 10.1186/1472-6750-10-52

G. Suo, B. Chen, J. Zhang, Z. Duan, Z. He et al., Effects of codon modification on human BMP2 gene expression in tobacco plants, Plant Cell Reports, vol.74, issue.Pt 2, pp.689-697, 2006.
DOI : 10.1007/s00299-006-0133-6

K. Fujiyama, R. Misaki, Y. Sakai, T. A. Omasa, and T. Seki, Change in glycosylation pattern with extension of endoplasmic reticulum retention signal sequence of mouse antibody produced by suspension-cultured tobacco BY2 cells, Journal of Bioscience and Bioengineering, vol.107, issue.2, pp.165-172, 2009.
DOI : 10.1016/j.jbiosc.2008.09.016

D. E. Webster, L. Wang, M. Mulcair, C. Ma, L. Santi et al., antigen in plants using a virus-based expression system, Plant Biotechnology Journal, vol.38, issue.9, pp.846-855, 2009.
DOI : 10.1111/j.1467-7652.2009.00447.x

H. S. Mason, J. M. Ball, J. J. Shi, X. Jiang, M. K. Estes et al., Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice., Proceedings of the National Academy of Sciences, vol.93, issue.11, pp.5335-5340, 1996.
DOI : 10.1073/pnas.93.11.5335

E. Gomez, S. C. Zoth, S. Asurmendi, C. A. Vazquez-rovere, and A. Berinstein, Expression of Hemagglutinin-Neuraminidase glycoprotein of Newcastle Disease Virus in agroinfiltrated Nicotiana benthamiana plants, Journal of Biotechnology, vol.144, issue.4, pp.337-340, 2009.
DOI : 10.1016/j.jbiotec.2009.09.015

M. Cabanes-macheteau, A. C. Fitchette-laine, C. Loutelier-bourhis, C. Lange, N. D. Vine et al., N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants, Glycobiology, vol.9, issue.4, pp.365-372, 1999.
DOI : 10.1093/glycob/9.4.365

J. Amani, S. L. Mousavi, S. A. Rafati, and A. H. Salmanian, Immunogenicity Of A Plant-Derived Edible Chimeric Espa, Intimin And Tir Immunogenic CCHFV virus glycoprotein 28, 2011.

L. Santi, L. Batchelor, Z. Huang, B. Hjelm, J. Kilbourne et al., An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles, Vaccine, vol.26, issue.15, pp.1846-1854, 2008.
DOI : 10.1016/j.vaccine.2008.01.053

R. Lombardi, P. Circelli, M. E. Villani, G. Buriani, L. Nardi et al., High-level HIV-1 Nef transient expression in Nicotiana benthamiana using the P19 gene silencing suppressor protein of Artichoke Mottled Crinckle Virus, BMC Biotechnology, vol.9, issue.1, p.96, 2009.
DOI : 10.1186/1472-6750-9-96

P. Saxena, Y. C. Hsieh, V. Y. Alvarado, F. Sainsbury, K. Saunders et al., Improved foreign gene expression in plants using a virus-encoded suppressor of RNA silencing modified to be developmentally harmless, Plant Biotechnology Journal, vol.426, issue.6, pp.703-712, 2011.
DOI : 10.1111/j.1467-7652.2010.00574.x

T. G. Kim, M. Y. Kim, and M. S. Yang, Cholera toxin B subunit-domain III of dengue virus envelope glycoprotein E fusion protein production in transgenic plants, Protein Expression and Purification, vol.74, issue.2, pp.236-241
DOI : 10.1016/j.pep.2010.07.013

S. Ashraf, P. K. Singh, D. K. Yadav, M. Shahnawaz, S. Mishra et al., High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice, Journal of Biotechnology, vol.119, issue.1, pp.1-14, 2005.
DOI : 10.1016/j.jbiotec.2005.06.009

F. Zhou, J. A. Badillo-corona, D. Karcher, N. Gonzalez-rabade, K. Piepenburg et al., High-level expression of human immunodeficiency virus antigens from the tobacco and tomato plastid genomes, Plant Biotechnology Journal, vol.52, issue.9, pp.897-913, 2008.
DOI : 10.1111/j.1467-7652.2008.00356.x

J. Liu, M. C. Dolan, M. A. Reidy, and C. L. Cramer, Expression of Bioactive Single-Chain Murine IL-12 in Transgenic Plants, Journal of Interferon & Cytokine Research, vol.28, issue.6, pp.381-392, 2008.
DOI : 10.1089/jir.2007.0129

F. A. Pizzuti and L. Daroda, Investigating recombinant protein exudation from roots of transgenic tobacco, Environmental Biosafety Research, vol.7, issue.4, pp.219-226, 2008.
DOI : 10.1051/ebr:2008020

S. A. Srivastava and A. K. Srivastava, Hairy Root Culture for Mass-Production of High-Value Secondary Metabolites, Critical Reviews in Biotechnology, vol.101, issue.1, pp.29-43, 2007.
DOI : 10.1007/BF00133014

D. Guzman, G. Walmsley, A. M. Webster, D. E. Hamill, and J. D. , Hairy roots cultures from different Solanaceous species have varying capacities to produce E. coli B-subunit heat-labile toxin antigen, Biotechnology Letters, vol.31, issue.12, 2011.
DOI : 10.1007/s10529-011-0710-9

D. A. Bente, J. B. Alimonti, W. J. Shieh, G. Camus, U. Stroher et al., Pathogenesis and Immune Response of Crimean-Congo Hemorrhagic Fever Virus in a STAT-1 Knockout Mouse Model, Journal of Virology, vol.84, issue.21, pp.11089-11100, 2010.
DOI : 10.1128/JVI.01383-10

P. N. Boyaka, M. Ohmura, K. Fujihashi, T. Koga, M. Yamamoto et al., Chimeras of Labile Toxin One and Cholera Toxin Retain Mucosal Adjuvanticity and Direct Th Cell Subsets Via Their B Subunit, The Journal of Immunology, vol.170, issue.1, pp.454-462, 2003.
DOI : 10.4049/jimmunol.170.1.454