J. Aerts, M. Gonzales, and S. Topalian, Selection of appropriate control genes to assess expression of tumor antigens using real-time RT-PCR, Biotechniques, vol.36, pp.84-97, 2004.

J. Binet, A. Auquier, G. Dighiero, and C. Chastang, A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis, Cancer, vol.42, issue.1, pp.198-206, 1981.
DOI : 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V

M. Catherwood, C. Matthews, R. Niblock, and E. Dobbin, ZAP-70 mRNA quantification in B-cell chronic lymphocytic leukaemia, European Journal of Haematology, vol.90, issue.4, pp.294-298, 2006.
DOI : 10.1038/sj.leu.2403748

L. Chen, Y. Zhang, W. Zheng, and Y. Wu, Distinctive IgVH gene segments usage and mutation status in Chinese patients with chronic lymphocytic leukemia, Leukemia Research, vol.32, issue.10, pp.1491-1498, 2008.
DOI : 10.1016/j.leukres.2008.02.005

B. Cheson, J. Bennett, K. Rai, and M. Grever, Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the national cancer institute-sponsored working group, American Journal of Hematology, vol.24, issue.3, pp.152-163, 1988.
DOI : 10.1002/ajh.2830290307

M. Crespo, F. Bosch, N. Villamor, and B. Bellosillo, ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia, New England Journal of Medicine, vol.348, issue.18, pp.1764-1775, 2003.
DOI : 10.1056/NEJMoa023143

R. Damle, T. Wasil, F. Fais, and F. Ghiotto, Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia, Blood, vol.94, pp.1840-1847, 1999.

D. Principe, M. , D. Poeta, G. Buccisano, F. Maurillo et al., Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia, Blood, vol.108, issue.3, pp.853-861, 2006.
DOI : 10.1182/blood-2005-12-4986

A. Ferrer, J. Ollila, G. Tobin, and B. Nagy, Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia, Cancer Genetics and Cytogenetics, vol.153, issue.1, pp.69-72, 2004.
DOI : 10.1016/j.cancergencyto.2003.12.016

T. Hamblin, Z. Davis, A. Gardiner, and D. Oscier, Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia, Blood, vol.94, pp.1848-1854, 1999.

T. Hamblin, J. Orchard, R. Ibbotson, and Z. Davis, CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease, Blood, vol.99, issue.3, pp.1023-1029, 2002.
DOI : 10.1182/blood.V99.3.1023

S. Ibrahim, M. Keating, K. Do, O. Brien, and S. , CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia, Blood, vol.98, issue.1, pp.181-186, 2001.
DOI : 10.1182/blood.V98.1.181

D. Kienle, C. Korz, B. Hosch, and A. Benner, Evidence for Distinct Pathomechanisms in Genetic Subgroups of Chronic Lymphocytic Leukemia Revealed by Quantitative Expression Analysis of Cell Cycle, Activation, and Apoptosis-Associated Genes, Journal of Clinical Oncology, vol.23, issue.16, pp.3780-3792, 2005.
DOI : 10.1200/JCO.2005.02.568

S. Kim, K. Chow, N. Kukoc-zivojnov, and S. Boehrer, Status, Leukemia & Lymphoma, vol.268, issue.10, pp.2037-2045, 2004.
DOI : 10.1016/S1074-7613(00)80422-7
URL : https://hal.archives-ouvertes.fr/in2p3-00847750

A. Krober, T. Seiler, A. Benner, and L. Bullinger, V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia, Blood, vol.100, pp.1410-1416, 2002.

A. Krober, J. Bloehdorn, S. Hafner, and A. Buhler, Mutation Status in Chronic Lymphocytic Leukemia, Journal of Clinical Oncology, vol.24, issue.6, pp.969-975, 2006.
DOI : 10.1200/JCO.2005.03.7184

C. Moreno and E. Montserrat, New prognostic markers in chronic lymphocytic leukemia, Blood Reviews, vol.22, issue.4, pp.211-219, 2008.
DOI : 10.1016/j.blre.2008.03.003

J. Orchard, R. Ibbotson, Z. Davis, and A. Wiestner, ZAP-70 expression and prognosis in chronic lymphocytic leukaemia, The Lancet, vol.363, issue.9403, pp.105-111, 2004.
DOI : 10.1016/S0140-6736(03)15260-9

K. Rai, A. Sawitsky, E. Cronkite, and A. Chanana, Advances in the Clinical Staging of Chronic Lymphocytic Leukemia, Clinical Chemistry, vol.57, issue.12, pp.219-234, 1975.
DOI : 10.1373/clinchem.2010.159004

L. Rassenti, L. Huynh, T. Toy, and L. Chen, ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia, New England Journal of Medicine, vol.351, issue.9, pp.893-901, 2004.
DOI : 10.1056/NEJMoa040857

R. Schroers, F. Griesinger, L. Trumper, and D. Haase, Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia, Leukemia, vol.74, issue.5, pp.750-758, 2005.
DOI : 10.1038/sj.leu.2403707

B. Stamatopoulos, N. Meuleman, B. Haibe-kains, and H. Duvillier, Quantification of ZAP70 mRNA in B Cells by Real-Time PCR Is a Powerful Prognostic Factor in Chronic Lymphocytic Leukemia, Clinical Chemistry, vol.53, issue.10, pp.1757-1766, 2006.
DOI : 10.1373/clinchem.2007.089326

A. Wiestner, A. Rosenwald, T. Barry, and G. Wright, ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile, Blood, vol.101, issue.>12, pp.4944-4951, 2003.
DOI : 10.1182/blood-2002-10-3306