A. Taher, H. Cappellini, and M. , Thalassemia intermedia: Revisited, Blood Cells, Molecules, and Diseases, vol.37, issue.1, pp.12-20, 2006.
DOI : 10.1016/j.bcmd.2006.04.005

C. Camaschella and M. Cappellini, Thalassemia intermedia, Haematologica, vol.80, issue.1, pp.58-68, 1995.

L. Oggiano, L. Guiso, L. Frogheri, G. Loudianos, P. Pistidda et al., A novel mediterranean ???????-thalassemia??? determinant containing the ??+27 and ????39 point mutations in cis, American Journal of Hematology, vol.296, issue.1, pp.81-84, 1994.
DOI : 10.1002/ajh.2830450113

C. Blau and G. Stamatoyannopoulos, Hemoglobin switching and its clinical implications, Curr Opin Hematol, vol.1, issue.2, pp.136-142, 1994.

T. Katsube and Y. Fukumaki, A Role for the Distal CCAAT Box of the ??-Globin Gene in Hb Switching1, The Journal of Biochemistry, vol.117, issue.1, pp.68-76, 1995.
DOI : 10.1093/oxfordjournals.jbchem.a124723

K. De-vooght, R. Van-wijk, P. Van-amstel, H. Van-solinge, and W. , Characterization of the ???16C>G sequence variation in the promoters of both HBG1 and HBG2: Convergent evolution of the human ??-globin genes, Blood Cells, Molecules, and Diseases, vol.39, issue.1, pp.70-74, 2007.
DOI : 10.1016/j.bcmd.2007.03.002

J. Gilman and T. Huisman, DNA sequence variation associated with elevated fetal G gamma globin production, Blood, vol.66, issue.4, pp.783-787, 1985.

A. Papachatzopoulou, P. Kaimakis, F. Pourfarzad, P. Menounos, P. Evangelakou et al., Increased gamma-globin gene expression in beta-thalassemia intermedia patients correlates with a mutation in 3'HS1

Y. Feng, R. Warin, T. Li, E. Olivier, A. Besse et al., The Human ??-Globin Locus Control Region Can Silence as Well as Activate Gene Expression, Molecular and Cellular Biology, vol.25, issue.10, pp.3864-3874, 2005.
DOI : 10.1128/MCB.25.10.3864-3874.2005

B. Tolhuis, R. Palstra, E. Splinter, F. Grosveld, and W. De-laat, Looping and Interaction between Hypersensitive Sites in the Active ??-globin Locus, Molecular Cell, vol.10, issue.6, pp.1453-1465, 2002.
DOI : 10.1016/S1097-2765(02)00781-5

G. Patrinos, M. De-krom, E. De-boer, A. Langeveld, A. Imam et al., Multiple interactions between regulatory regions are required to stabilize an active chromatin hub, Genes & Development, vol.18, issue.12, pp.1495-1509, 2004.
DOI : 10.1101/gad.289704

R. Palstra, B. Tolhuis, E. Splinter, R. Nijmeijer, F. Grosveld et al., The ??-globin nuclear compartment in development and erythroid differentiation, Nature Genetics, vol.35, issue.2, pp.190-194, 2003.
DOI : 10.1038/ng1244

M. Haghi, A. Feizi, C. Harteveld, N. Pouladi, M. Feizi et al., -Thalassemia Mutation [Frameshift Codons 25/26 (+T)] Causes ??-Thalassemia Intermedia in an Iranian Family, Hemoglobin, vol.70, issue.3, pp.75-80, 2008.
DOI : 10.1086/301859
URL : https://hal.archives-ouvertes.fr/hal-00140674

S. Miller, D. Dykes, H. Polesky, M. Karimipoor, S. Zeinali et al., A simple salting out procedure for extracting DNA from human nucleated cells, Nucleic Acids Research, vol.16, issue.3, pp.1215-1231, 1977.
DOI : 10.1093/nar/16.3.1215

A. Kiani, Y. Shirkhani, B. Delfan, M. Kashi, Y. Mortazavi et al., The Molecular Analysis of ??-Thalassemia Mutations in Lorestan Province, Iran, Hemoglobin, vol.57, issue.3, pp.88-95, 2006.
DOI : 10.1081/HEM-120002938

M. Papadakis, G. Patrinos, P. Tsaftaridis, A. Loutradi-anagnostou, S. Samakoglu et al., A comparative study of Greek nondeletional hereditary persistence of fetal hemoglobin and beta-thalassemia compound heterozygotes Nucleotide changes in the gamma-globin promoter and the (AT)xNy(AT)z polymorphic sequence of beta LCRHS-2 region associated with altered levels of HbF Genotypic heterogeneity and correlation to intergenic haplotype within high HbF beta-thalassemia intermedia, J Mol Med. Eur J Hum Genet. Eur J Haematol, vol.80, issue.764, pp.243-247, 1999.

M. Akbari, P. Izadi, M. Izadyar, K. Kyriacou, and M. Kleanthous, Molecular Basis of Thalassemia Intermedia in Iran, Hemoglobin, vol.95, issue.3, pp.461-470, 2008.
DOI : 10.1080/03630260701641245