MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines.

Emna Ayari-Fakhfakh (1) , Tânia Zaverucha Do Valle (2) , Laurent Guillemot (2) , Jean-Jacques Panthier (2) , Michèle Bouloy (3) , Abdeljelil Ghram (1) , Emmanuel Albina (4) , Catherine Cêtre-Sossah (4)

1 Institut Pasteur de Tunis
2 Génétique Fonctionnelle de la Souris
3 Génétique Moléculaire des Bunyavirus
4 UMR CMAEE - Contrôle des maladies animales exotiques et émergentes

Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.

Domaines: Santé publique et épidémiologie

Emna Ayari-Fakhfakh, Tânia Zaverucha Do Valle, Laurent Guillemot, Jean-Jacques Panthier, Michèle Bouloy, et al.. MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines.. Journal of General Virology, 2012, 93 (Pt 7), pp.1456-64. ⟨10.1099/vir.0.042754-0⟩. ⟨pasteur-00751378⟩