Skip to Main content Skip to Navigation
Journal articles

MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines.

Abstract : Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.
Document type :
Journal articles
Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-00751378
Contributor : Institut Pasteur Tunis <>
Submitted on : Tuesday, November 13, 2012 - 12:04:57 PM
Last modification on : Saturday, June 6, 2020 - 4:14:02 PM

Links full text

Identifiers

Collections

Citation

Emna Ayari-Fakhfakh, Tânia Zaverucha Do Valle, Laurent Guillemot, Jean-Jacques Panthier, Michèle Bouloy, et al.. MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines.. Journal of General Virology, Microbiology Society, 2012, 93 (Pt 7), pp.1456-64. ⟨10.1099/vir.0.042754-0⟩. ⟨pasteur-00751378⟩

Share

Metrics

Record views

343