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Journal articles
Synthesis and Biological Evaluation of Coumarin Derivatives as Inhibitors of Mycobacterium bovis (BCG).
Abstract : The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one-pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide-based multicomponent condensation reactions. These compounds were evaluated for anti-mycobacterium activity against Mycobacterium bovis (Bacillus Calmette-Guerin). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e, 7l, and 7m showed high anti-tuberculosis activity.
Cited literature [28 references]
https://hal-riip.archives-ouvertes.fr/pasteur-00753191
Contributor : Soroush Sardari Connect in order to contact the contributor
Submitted on : Sunday, November 18, 2012 - 8:33:14 AM
Last modification on : Wednesday, September 23, 2020 - 10:48:02 AM
Long-term archiving on: : Saturday, December 17, 2016 - 11:50:31 AM
Contributor : Soroush Sardari Connect in order to contact the contributor
Submitted on : Sunday, November 18, 2012 - 8:33:14 AM
Last modification on : Wednesday, September 23, 2020 - 10:48:02 AM
Long-term archiving on: : Saturday, December 17, 2016 - 11:50:31 AM