M. Ranby, N. Bergsdorf, G. Pohl, and P. Wallen, Isolation of two variants of native one-chain tissue plasminogen activator, FEBS Letters, vol.78, issue.2, pp.289-292, 1982.
DOI : 10.1016/0014-5793(82)80936-8

K. Benchenane, J. P. Lopez-atalaya, M. Fernandez-monreal, O. Touzani, and D. Vivien, Equivocal roles of tissue-type plasminogen activator in stroke-induced injury, Trends in Neurosciences, vol.27, issue.3, pp.155-160, 2004.
DOI : 10.1016/j.tins.2003.12.011

J. Travis and G. S. Salvesen, Human Plasma Proteinase Inhibitors, Annual Review of Biochemistry, vol.52, issue.1, pp.655-709, 1983.
DOI : 10.1146/annurev.bi.52.070183.003255

R. Carrell and D. R. Boswell, Serpins, Proteinase Inhibitors, pp.403-420, 1986.
DOI : 10.1002/047120918X.emb1410

L. A. Erickson, M. H. Ginsberg, and D. J. Loskutoff, Detection and partial characterization of an inhibitor of plasminogen activator in human platelets., Journal of Clinical Investigation, vol.74, issue.4, pp.1465-1472, 1984.
DOI : 10.1172/JCI111559

C. M. Hekman and D. J. Loskutoff, Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator, Archives of Biochemistry and Biophysics, vol.262, issue.1, pp.199-210, 1988.
DOI : 10.1016/0003-9861(88)90182-8

D. L. Higgins and G. A. Vehar, Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin, Biochemistry, vol.26, issue.24, pp.7786-7791, 1987.
DOI : 10.1021/bi00398a038

O. F. Wagner, C. De-vries, C. Hohmann, H. Veerman, and H. Pannekoek, Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA., Journal of Clinical Investigation, vol.84, issue.2, pp.647-655, 1989.
DOI : 10.1172/JCI114211

R. V. Shohet, S. Spitzer, E. L. Madison, R. Bassel-duby, M. J. Gething et al., Inhibitor-resistant tissue-type plasminogen activator: an improved thrombolytic agent in vitro, Thromb. Haemost, vol.71, p.124, 1994.

N. F. Paoni, B. A. Keyt, C. J. Refino, A. M. Chow, H. V. Nguyen et al., A slow clearing, fibrin?specific , PAI?1 resistant variant of t?PA, Thromb. Haemost, vol.70, pp.307-312, 1993.

X. K. Li, H. R. Lijnen, L. Nelles, H. B. Van, J. M. Stassen et al., Biochemical and biologic properties of rt-PA del (K296-G302), a recombinant human tissue-type plasminogen activator deletion mutant resistant to plasminogen activator inhibitor-1, Blood, vol.79, pp.417-429, 1992.

T. K. Nordt and C. Bode, Thrombolysis: newer thrombolytic agents and their role in clinical medicine, Heart, vol.89, issue.11, pp.1358-1362, 2003.
DOI : 10.1136/heart.89.11.1358

D. B. Baruah, R. N. Dash, M. R. Chaudhari, and S. S. Kadam, Plasminogen activators: A comparison, Vascular Pharmacology, vol.44, issue.1, pp.1-9, 2006.
DOI : 10.1016/j.vph.2005.09.003

W. D. Weaver, The role of thrombolytic drugs in the management of myocardial infarction: Comparative clinical trials, European Heart Journal, vol.17, issue.suppl F, pp.9-15, 1996.
DOI : 10.1093/eurheartj/17.suppl_F.9

F. Davami, S. Sardari, A. Majidzadeh, M. Hemayatkar, F. Barkhrdari et al., Expression of a Novel Chimeric Truncated t-PA in CHO Cells Based on in Silico Experiments, Journal of Biomedicine and Biotechnology, vol.137, issue.6, pp.108-159, 2010.
DOI : 10.1023/B:BILE.0000003992.09492.4b
URL : https://hal.archives-ouvertes.fr/pasteur-00821614

P. J. Burck, D. H. Berg, M. W. Warrick, D. T. Berg, J. D. Walls et al., Characterization of a modified human tissue plasminogen activator comprising a kringle?2 and a protease domain, J. Biol. Chem, vol.265, pp.5170-5177, 1990.

U. Martin, L. Dorge, and S. Fischer, Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis, British Journal of Pharmacology, vol.16, issue.suppl., pp.271-276
DOI : 10.1111/j.1476-5381.1996.tb15398.x

G. N. Levine, M. N. Ali, and A. I. Schafer, Antithrombotic Therapy in Patients With Acute Coronary Syndromes, Archives of Internal Medicine, vol.161, issue.7, pp.937-948, 2001.
DOI : 10.1001/archinte.161.7.937

J. J. Emeis, C. M. Van-den-hoogen, and D. Jense, Hepatic clearance of tissue-type plasminogen activator in rats, Thromb. Haemost, vol.54, pp.661-664, 1985.

K. Ouriel, B. Katzen, M. Mewissen, P. Flick, D. G. Clair et al., Reteplase in the Treatment of Peripheral Arterial and Venous Occlusions: A Pilot Study, Journal of Vascular and Interventional Radiology, vol.11, issue.7, pp.849-854, 2000.
DOI : 10.1016/S1051-0443(07)61799-0

E. L. Madison, E. J. Goldsmith, R. D. Gerard, M. J. Gething, J. F. Sambrook et al., Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1., Proceedings of the National Academy of Sciences, vol.87, issue.9, pp.3530-3533, 1990.
DOI : 10.1073/pnas.87.9.3530

P. Bagchi, M. Mahesh, and R. Somashekhar, Pharmaco-Informatics: Homology Modelling of the Target Protein (GP1, 2) for Ebola Hemorrhagic Fever and Predicting an Ayurvedic Remediation of the Disease, Journal of Proteomics & Bioinformatics, vol.02, issue.07, pp.287-294, 2009.
DOI : 10.4172/jpb.1000088

D. Pennica, W. E. Holmes, W. J. Kohr, R. N. Harkins, G. A. Vehar et al., Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli, Nature, vol.2, issue.5897, pp.214-221, 1983.
DOI : 10.1038/301214a0

S. A. Rouf, M. Moo-young, and Y. Chisti, Tissue-type plasminogen activator: Characteristics, applications and production technology, Biotechnology Advances, vol.14, issue.3, pp.239-266, 1996.
DOI : 10.1016/0734-9750(96)00019-5

A. Upshall, A. A. Kumar, M. C. Bailey, M. D. Parker, M. A. Favreau et al., Secretion of Active Human Tissue Plasminogen Activator from the Filamentous Fungus Aspergillus Nidulans, Bio/Technology, vol.33, issue.12, pp.1301-1304, 1987.
DOI : 10.1084/jem.148.1.223

M. Soleimani, F. Mahboudi, N. Davoudi, A. Amanzadeh, M. Azizi et al., Expression of human tissue plasminogen activator in the trypanosomatid protozoan Leishmania tarentolae, Biotechnol. Appl. Biochem, vol.48, pp.55-61, 2007.

G. M. Opdenakker and P. It, Protease inhibitors , a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors, EP0736302), 1996.

A. Hamsten, F. U. De, G. Walldius, G. Dahlen, A. Szamosi et al., PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION, The Lancet, vol.330, issue.8549, pp.3-9, 1987.
DOI : 10.1016/S0140-6736(87)93050-9

E. L. Madison, E. J. Goldsmith, R. D. Gerard, M. J. Gething, and J. F. Sambrook, Serpin-resistant mutants of human tissue-type plasminogen activator, Nature, vol.339, issue.6227, pp.721-724, 1989.
DOI : 10.1038/339721a0

G. Deleage and B. Roux, An algorithm for protein secondary structure prediction based on class prediction, "Protein Engineering, Design and Selection", vol.1, issue.4, pp.289-294, 1987.
DOI : 10.1093/protein/1.4.289
URL : https://hal.archives-ouvertes.fr/hal-00313814

C. Heussen and E. B. Dowdle, Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates, Analytical Biochemistry, vol.102, issue.1, pp.196-202, 1980.
DOI : 10.1016/0003-2697(80)90338-3

B. V. Pandya, J. L. Gabriel, J. O-'brien, and A. Z. Budzynski, Polymerization site in the .beta. chain of fibrin: mapping of the B.beta.1-55 sequence, Biochemistry, vol.30, issue.1, pp.162-168, 1991.
DOI : 10.1021/bi00215a024

J. Chmielewska, M. Ranby, and B. Wiman, Evidence for a rapid inhibitor to tissue plasminogen activator in plasma, Thrombosis Research, vol.31, issue.3, pp.427-436, 1983.
DOI : 10.1016/0049-3848(83)90407-3

C. Krishnamurti, B. Keyt, P. Maglasang, and B. M. Alving, PAI-1-resistant t-PA: low doses prevent fibrin deposition in rabbits with increased PAI-1 activity, Blood, vol.87, pp.14-19, 1996.

G. George, D. J. , and .. , Purified type I and type II t, 1989.

U. Kohnert, R. Rudolph, J. H. Verheijen, E. J. Weening-verhoeff, A. Stern et al., Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06, Protein Eng, vol.5, pp.22-93, 1992.