The Structure of GABP/: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA, Science, vol.279, issue.5353, pp.1037-1041, 1998. ,
DOI : 10.1126/science.279.5353.1037
Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a, Structure, vol.6, issue.10, pp.1279-1290, 1998. ,
DOI : 10.1016/S0969-2126(98)00128-2
The retinoblastoma tumour suppressor in development and cancer, Nature Reviews Cancer, vol.2, issue.12, pp.910-917, 2002. ,
DOI : 10.1038/nrc950
Simulation of different truncated p16 forms and in silico study of interaction with Cdk4, Cancer Inform, vol.7, pp.1-11, 2009. ,
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts, 1999. ,
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide from p16CDKN2/INK4A, Current Biology, vol.6, issue.1, pp.84-91, 1996. ,
DOI : 10.1016/S0960-9822(02)00425-6
Arrest in the AtT20 Pituitary Tumor Cell Line, Molecular Endocrinology, vol.13, issue.11, pp.1801-1810, 1999. ,
DOI : 10.1210/mend.13.11.0374
Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas, Cancer Res, vol.59, pp.3783-3789, 1999. ,
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers, Cancer Res, vol.55, pp.4525-4530, 1995. ,
Tumour-derived p16 alleles encoding proteins defective in cell-cycle
inhibition, Nature, vol.375, issue.6531, pp.506-510, 1995. ,
DOI : 10.1038/375506a0
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines., Proceedings of the National Academy of Sciences, vol.92, issue.22, pp.10436-10440, 1995. ,
DOI : 10.1073/pnas.92.22.10436
Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes, Molecular and Cellular Biology, vol.19, issue.3, pp.1981-1989, 1999. ,
DOI : 10.1128/MCB.19.3.1981
Ankyrin for clues about the function 0fp16INK4a, Nature Structural Biology, vol.6, issue.2, pp.85-88, 1998. ,
DOI : 10.1093/hmg/6.12.2061
The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats, J Biol Chem, vol.268, pp.22703-22709, 1993. ,
p16INK4A Sensitizes Human Leukemia Cells to FAS- and Glucocorticoid-induced Apoptosis via Induction of BBC3/Puma and Repression of MCL1 and BCL2, Journal of Biological Chemistry, vol.284, issue.45, pp.30933-30940, 2009. ,
DOI : 10.1074/jbc.M109.051441
Cyclin D-dependent kinases, INK4 inhibitors and cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1602, issue.1, pp.73-87, 2002. ,
DOI : 10.1016/S0304-419X(02)00037-9
Retinoblastoma protein family in cell cycle and cancer: A review, Journal of Cellular Biochemistry, vol.18, issue.3, pp.418-430, 1996. ,
DOI : 10.1002/(SICI)1097-4644(199609)62:3<418::AID-JCB12>3.0.CO;2-E
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma., Molecular and Cellular Biology, vol.16, issue.7, pp.3844-3852, 1996. ,
DOI : 10.1128/MCB.16.7.3844
Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors, Journal of Molecular Biology, vol.287, issue.5, pp.821-828, 1999. ,
DOI : 10.1006/jmbi.1999.2640
Expression of Cell-Cycle Mediators in Ovarian Cancer Cells after Transfection with p16INK4a, p21WAF1/Cip-1, and p53, p21(WAF1/Cip-1), and p53, pp.543-548, 2001. ,
DOI : 10.1006/gyno.2001.6438
Tumor cell senescence in cancer treatment, Cancer Res, vol.63, pp.2705-2715, 2003. ,
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a, Nature, vol.395, pp.237-243, 1998. ,
The Tumor Suppressor Protein p16INK4a, Experimental Cell Research, vol.237, issue.1, pp.7-13, 1997. ,
DOI : 10.1006/excr.1997.3824
CDKN2A (p16INK4A) somatic and germline mutations, Human Mutation, vol.9, issue.4, pp.294-303, 1996. ,
DOI : 10.1002/(SICI)1098-1004(1996)7:4<294::AID-HUMU2>3.0.CO;2-9
Sequential Unfolding of Ankyrin Repeats in Tumor Suppressor p16, Structure, vol.11, issue.1, pp.67-73, 2003. ,
DOI : 10.1016/S0969-2126(02)00929-2
Stability and folding of the tumour suppressor protein p16, Journal of Molecular Biology, vol.285, issue.4, pp.1869-1886, 1999. ,
DOI : 10.1006/jmbi.1998.2420
through Molecular Dynamics Simulations, Journal of Biomolecular Structure and Dynamics, vol.12, issue.3, pp.347-358, 2002. ,
DOI : 10.1093/bioinformatics/15.4.327
The retinoblastoma protein and cell cycle control, Cell, vol.81, issue.3, pp.323-330, 1995. ,
DOI : 10.1016/0092-8674(95)90385-2
Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells, Oncogene, vol.11, pp.971-976, 1995. ,
The co-transfection of p16INK4a and p14ARF genes into human lung cancer cell line A549 and the effects on cell growth and chemosensitivity, Colloids and Surfaces B: Biointerfaces, vol.46, issue.3, pp.188-196, 2005. ,
DOI : 10.1016/j.colsurfb.2005.10.006
Mutational effects on the p16INK4a tumor suppressor protein, Cancer Res, vol.55, pp.2503-2506, 1995. ,
Analysis of p16INK4aand Its Interaction with CDK4, Biochemical and Biophysical Research Communications, vol.218, issue.1, pp.254-259, 1996. ,
DOI : 10.1006/bbrc.1996.0045
Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors, JNCI Journal of the National Cancer Institute, vol.91, issue.18, pp.1569-1574, 1999. ,
DOI : 10.1093/jnci/91.18.1569
Tumor suppressor INK4: comparisons of conformational properties between p16INK4A and p18INK4C, Journal of Molecular Biology, vol.294, issue.1, pp.201-211, 1999. ,
DOI : 10.1006/jmbi.1999.3231
A minimum folding unit in the ankyrin repeat protein p16INK4, Journal of Molecular Biology, vol.299, issue.4, pp.1121-1132, 2000. ,
DOI : 10.1006/jmbi.2000.3803