In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species.

Abstract : The extract from Artemisia annua, containing artemisinin, has been proven active against multidrug resistant Plasmodium falciparum in previous studies. The purpose of this paper was to study five Artemisia species from Iran for their in vitro and in vivo antimalarial property and detection of artemisinin in the active species by chromatographic and spectroscopic methods including nuclear magnetic resonance (NMR) spectroscopy. Dried plants were extracted by 80% ethanol, and total extracts were investigated for antiplasmodial property and artemisinin content by TLC, HPLC, and (1)H-NMR techniques. Two plants (A. annua L. and Artemisia absinthium L.) showed good antiplasmodial activity against multidrug resistant and sensitive strain of P. falciparum. A. absinthium and A. annua at concentrations of 200 mg/kg for 4 days reduced parasitemia in BALB/C mice infected with Plasmodium bergei by 94.28% and 83.28%, respectively, but we could not detect artemisinin in all plants studied in this research. The antiplasmodial property of these two herbs is possibly related to essential oils that present in high amounts in their extracts.
Document type :
Journal articles
Complete list of metadatas

Cited literature [27 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-00753298
Contributor : Soroush Sardari <>
Submitted on : Monday, November 19, 2012 - 9:00:04 AM
Last modification on : Wednesday, October 17, 2018 - 12:40:02 PM
Long-term archiving on : Saturday, December 17, 2016 - 12:25:19 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Ali Ramazani, Soroush Sardari, Sedigheh Zakeri, Behrouz Vaziri. In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species.. Parasitology Research, Springer Verlag (Germany), 2010, 107 (3), pp.593-9. ⟨10.1007/s00436-010-1900-4⟩. ⟨pasteur-00753298⟩

Share

Metrics

Record views

135