Skip to Main content Skip to Navigation
Journal articles

Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients.

Abstract : In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor(LACK), alpha tubulin (x2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates.
Document type :
Journal articles
Complete list of metadatas

Cited literature [29 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-00755317
Contributor : Behrouz Vaziri <>
Submitted on : Wednesday, November 21, 2012 - 8:17:12 AM
Last modification on : Wednesday, October 14, 2020 - 3:48:27 AM
Long-term archiving on: : Saturday, December 17, 2016 - 12:40:26 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

  • HAL Id : pasteur-00755317, version 1
  • PUBMED : 22571094

Collections

Citation

H. Hajjaran, B. Azarian, M. Mohebali, R. Hadighi, A. Assareh, et al.. Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients.. Eastern Mediterranean Health Journal, World Health Organization (WHO), 2012, 18 (2), pp.165-171. ⟨pasteur-00755317⟩

Share

Metrics

Record views

130