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Journal articles

Les sélectines : acteurs de l'adhérence cellulaire et potentiel cible thérapeutique

Abstract : Selectins belong to the family of adhesion molecules that recognize sugars as ligands through their Carbohydrate Recognition Domain (CRD). There are three types of selectin: the L-selectin (CD62L), which is constitutively expressed by most leukocyte populations, the P-selectin (CD62P) is found on activated platelets and endothelial cells, and the E-selectin (CD62E) expressed by activated endothelial cells. These three molecules exhibit high homology in their structures. Selectin-ligand interactions are among the most studied protein-glycan interactions in biology. The selectins and theirs ligands are involved in regulating inflammatory and immunological events that occur at the interface of the bloodstream and vessel walls. Their molecular partners are surface glycoconjugates harboring groups of the sialyl-Lewis antigens. This review presents an inventory of our current knowledge on the structures and functions of selectins and their ligands. We also provide an update on their involvement in pathophysiological processes, especially during inflammation and tumor development.
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Contributor : Institut Pasteur Tunis Connect in order to contact the contributor
Submitted on : Saturday, May 11, 2013 - 11:04:24 PM
Last modification on : Thursday, October 21, 2021 - 4:00:56 AM
Long-term archiving on: : Monday, August 12, 2013 - 2:25:10 AM


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  • HAL Id : pasteur-00755430, version 1
  • PUBMED : 23461138



Jed J. Jebali, Charlotte Ch Jeanneau, Amine A. Bazaa, Sylvie S. Mathieu, Mohamed M. El Ayeb, et al.. Les sélectines : acteurs de l'adhérence cellulaire et potentiel cible thérapeutique. Archives de l'Institut Pasteur de Tunis, 2011, 88 (1-4), pp.3-18. ⟨pasteur-00755430⟩



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