Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.

Abstract : The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for antiviral activity against viruses belonging to different taxonomic groups.
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Maya Spasova, Stefan Philipov, L. Nikolaeva-Glomb, A. S. Galabov, Ts Milkova. Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.. Bioorganic and Medicinal Chemistry, Elsevier, 2008, 16 (15), pp.7457-61. ⟨10.1016/j.bmc.2008.06.010⟩. ⟨pasteur-00755461⟩

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