Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.

Maya Spasova (1, 2) , Stefan Philipov (3) , L. Nikolaeva-Glomb (4) , A. S. Galabov (4) , Ts Milkova (1, 3)

1 South-West University "Neofit Rilski"
2 Institute of Molecular Biology
3 Institute of Organic Chemistry, Centre of Phytochemistry
4 Institut Stephan Angeloff

The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for antiviral activity against viruses belonging to different taxonomic groups.

Mots clés: Glaucine; 3-Aminoglaucine; 3-Aminomethylglaucine; Cinnamic acids; Antioxidant effect; DPPH* test; Antiviral activity

Domaines: Microbiologie et Parasitologie

Maya Spasova, Stefan Philipov, L. Nikolaeva-Glomb, A. S. Galabov, Ts Milkova. Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.. Bioorganic and Medicinal Chemistry, 2008, 16 (15), pp.7457-61. ⟨10.1016/j.bmc.2008.06.010⟩. ⟨pasteur-00755461⟩