Skip to Main content Skip to Navigation
New interface
Journal articles

Synergistic drug combinations against the in vitro replication of Coxsackie B1 virus.

Lubomira Nikolaeva-Glomb 1 Angel S Galabov 1, * 
* Corresponding author
Abstract : The existence of synergistic drug combinations against the in vitro replication of poliovirus type 1 (Mahoney) (PV-1) had been established in our previous work. The objective of the present study was to test the combined effects of the different drugs against another representative of the enterovirus genus, i.e. Coxsackievirus B1 (CBV-1). Dual combinations of enviroxime, disoxaril, arildone, PTU-23, HBB and S-7 were evaluated. The susceptibility of CBV-1 to the individual effects of the inhibitors was compared to that of PV-1. CBV-1 was more sensitive to enviroxime, S-7, PTU-23 and HBB and less sensitive to the effects of disoxaril and arildone. The effect of most dual drug combinations tested against CBV-1 replication was additive or synergistic. Enviroxime and S-7, enviroxime and PTU-23, disoxaril and HBB, disoxaril and PTU-23, arildone and HBB, arildone and PTU-23, S-7 and HBB revealed a strong synergistic effect. Synergy against CBV-1 replication was stronger as compared to that noted for the same drug combinations against PV-1 replication.
Document type :
Journal articles
Complete list of metadata
Contributor : Petar Grozdanov Connect in order to contact the contributor
Submitted on : Wednesday, November 21, 2012 - 12:42:25 PM
Last modification on : Monday, October 8, 2018 - 5:44:06 PM
Long-term archiving on: : Saturday, December 17, 2016 - 1:02:46 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Lubomira Nikolaeva-Glomb, Angel S Galabov. Synergistic drug combinations against the in vitro replication of Coxsackie B1 virus.. Antiviral Research, 2004, 62 (1), pp.9-19. ⟨10.1016/j.antiviral.2003.11.001⟩. ⟨pasteur-00755462⟩



Record views