Skip to Main content Skip to Navigation
Journal articles

Multiple gene status in Helicobacter pylori strains and risk of gastric cancer development.

Abstract : BACKGROUND/AIM: The identification of the vacA intermediate region has provided new insights into the role of vacA heterogeneity in relation to gastro-duodenal pathogenesis. The aim of this study was to assess vacA polymorphism in Iranian Helicobacter pylori strains and its association with cagA as a major virulence determinant, gastric histopathology and disease. METHODS: vacA polymorphism and serum antibody responses were studied in 207 H. pylori-infected (139 NUD, 34 PUD, and 34 GC) patients and correlated with gastric histopathology. RESULTS: Multivariate logistic regression analysis found intermediate region typing superior to signal or mid region typing for screening high risk patients. vacA i1 allele was identified as an independent predictor of dysplasia (OR = 9.044; 95% CI: 1.11-73.33). Possession of s1/i1/cagA(+) strains was also identified as a predictor of intestinal metaplasia (OR = 3; 95% CI: 1.13-7.95), dysplasia (OR = 9.9; 95% CI: 1.23-80.86) and risk of GC (OR = 6.9; 95% CI: 2.5-18.66) as well as induction of anti-VacA sero-positivity (OR = 5.04; 95% CI: 1.8-13.6). Anti-VacA serology correctly detected 83.8% of s1/i1/cagA(+) strains carried by high-risk patients. CONCLUSIONS: The current study emphasizes the implication of vacA polymorphic structure, especially the s1/i1/cagA(+) genotype, in increasing the risk of GC by revealing their association with gastric pre-neoplastic changes and their reflection in VacA sero-positivity which encourages the application of noninvasive procedures in population screening.
Document type :
Journal articles
Complete list of metadata

Cited literature [18 references]  Display  Hide  Download
Contributor : Marjan Mohammadi Connect in order to contact the contributor
Submitted on : Monday, December 10, 2012 - 7:09:30 AM
Last modification on : Wednesday, October 14, 2020 - 3:45:08 AM
Long-term archiving on: : Saturday, December 17, 2016 - 11:16:06 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Masoumeh Douraghi, Yeganeh Talebkhan, Hojjat Zeraati, Fatemeh Ebrahimzadeh, Azin Nahvijoo, et al.. Multiple gene status in Helicobacter pylori strains and risk of gastric cancer development.. Digestion, Karger, 2009, 80 (3), pp.200-7. ⟨10.1159/000229774⟩. ⟨pasteur-00762980⟩



Record views