Cooperative genotyping for Helicobacter pylori virulence determinants strengthens the predictive value of gastric cancer risk assessment.

Masoumeh Douraghi (1, 2) , Yeganeh Talebkhan (1) , Hojjat Zeraati (2) , Marjan Mohammadi (1)

1 Biotechnology Research Center
2 School of Public Health [Teheran]

Heterogeneous geneticprofilesof Helicobacter pylori are con- sidered askeycomponentsofhost-pathogen-environmenttriad interaction andplaycrucialrolesinthegastriccarcinogenesis [1]. Persistent colonisationandmaintenanceof H. pylori in theharsh environment ofthestomachareattributedtoaseriesofvirulence determinants. Twopotentpolymorphicsecretorytoxins; vacA and cagA and thefunctionallyactiveadhesin babA2 are identifiedasthe more decisivevirulencemarkersinthedevelopmentofthemore severe diseaseoutcomes.

Mots clés: genotyping; Helicobacter pylori; virulence; gastric cancer; risk assessment

Domaines: Biotechnologie; Biotechnologies

Masoumeh Douraghi, Yeganeh Talebkhan, Hojjat Zeraati, Marjan Mohammadi. Cooperative genotyping for Helicobacter pylori virulence determinants strengthens the predictive value of gastric cancer risk assessment.. Digestive and Liver Disease, 2010, 42 (9), pp.662-3. ⟨10.1016/j.dld.2010.01.010⟩. ⟨pasteur-00783933⟩