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Chemokine-based immunotherapy: delivery systems and combination therapies.

Elham Mohit 1 Sima Rafati 1, *
* Corresponding author
Abstract : A major role of chemokines is to mediate leukocyte migration through interaction with G-protein-coupled receptors. Various delivery systems have been developed to utilize the chemokine properties for combating disease. Viral and mutant viral vectors expressing chemokines, genetically modified dendritic cells with chemokine or chemokine receptors, engineered chemokine-expressing tumor cells and pDNA encoding chemokines are among these methods. Another approach for inducing a targeted immune response is fusion of a targeting antibody or antibody fragment to a chemokine. In addition, chemokines induce more effective antitumor immunity when used as adjuvants. In this regard, chemokines are codelivered along with antigens or fused as a targeting unit with antigenic moieties. In this review, several chemokines with their role in inducing immune response against different diseases are discussed, with a major emphasis on cancer.
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https://hal-riip.archives-ouvertes.fr/pasteur-00789206
Contributor : Sima Rafati <>
Submitted on : Sunday, February 17, 2013 - 9:47:39 AM
Last modification on : Wednesday, October 14, 2020 - 4:10:33 AM

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Elham Mohit, Sima Rafati. Chemokine-based immunotherapy: delivery systems and combination therapies.. Journal of immunotherapy : official journal of the Society for Biological Therapy, Raven Press Publishers, 2012, 4 (8), pp.807-40. ⟨10.2217/imt.12.72⟩. ⟨pasteur-00789206⟩

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