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Journal articles
Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters
Veasna Duong
1
Matthew R. Henn
2
Cameron Simmons
3
Chantha Ngan
4
Bunthin Y
1
Laurent Gavotte
5
Alain Viari
6
Sivuth Ong
1
Rekol Huy
4
Niall J. Lennon
2
Sowath Ly
1
Sirenda Vong
1
Bruce W. Birren
6
Jeremy J. Farrar
3
Vincent Deubel
1
Roger Frutos
7
Philippe Buchy
1, *
*
Corresponding author
6
BAMBOO - An algorithmic view on genomes, cells, and environments
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Bunthin Y 1
Author
Laurent Gavotte 5
Mail :
Author IdHAL : lgavotte
Alain Viari 6
Mail :
Author IdHAL : alain-viari ORCID : https://orcid.org/0000-0002-1329-7777
Sivuth Ong 1
Author
Philippe Buchy 1
Mail :
Correspondent author
1
Institut Pasteur du Cambodge (BP 983 - 5 , Boulevard Monivong, Phnom Penh - Cambodia)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
BROAD INSTITUTE - Broad Institute of MIT and Harvard (Cambridge, MA 02142 - United States)
- HMS - Harvard Medical School [Boston] (25 Shattuck Street Boston, MA 02115 - United States)
- MIT - Massachusetts Institute of Technology (77 Massachusetts Ave, Cambridge, MA 02139 - United States)
- Massachusetts General Hospital [Boston] (55 Fruit Street Boston, MA 02114 - United States)
3
OUCRU - Oxford University Clinical Research Unit [Ho Chi Minh City] (190 Ben Ham Tu, District 5, Ho Chi Minh City - Vietnam)
4
CNM - National Center of Parasitology (National Center for Parasitology, Entomology and Malaria Control #372 Monivong Blvd (Corner St.322) - Cambodia)
- National Malaria Center [Phnom Penh] (372 boulevard Monivong, Phnom Penh - Cambodia)
5
UM2 - Université Montpellier 2 - Sciences et Techniques (Place Eugène Bataillon - 34095 Montpellier cedex 5 - France)
6
BAMBOO - An algorithmic view on genomes, cells, and environments (Laboratoire de Biométrie et Biologie Évolutive. UMR CNRS 5558 Campus de La Doua - Université Claude Bernard - Lyon 1 Bâtiment Grégoire Mendel - 16 rue Raphael Dubois 69 100 Villeurbanne -- INRIA Grenoble - Rhône-Alpes Inovallée 655 avenue de l'Europe -Montbonnot 38 334 Saint Ismier Cedex France - France)
- Inria Grenoble - Rhône-Alpes (Inovallée
655 avenue de l'Europe
38330 Montbonnot - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
- LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
- VAS - VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique) - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5558 (France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
7
UMR INTERTRYP - Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (Campus International de Baillarguet TA A-17/G 34398 Montpellier cedex 5 - France)
- Cirad - Centre de Coopération Internationale en Recherche Agronomique pour le Développement : UMR17 (Siège 42, rue Scheffer 75116 Paris - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- IRD - Institut de Recherche pour le Développement : UMR177 (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- UB - Université de Bordeaux (35, place Pey Berland - 33076 Bordeaux - France)
Abstract : The Dengue National Control Program was established in Cambodia in 2000 and has reported between 10,000 and 40,000 dengue cases per year with a case fatality rate ranging from 0.7 to 1.7. In this study 39 DENV-2 and 57 DENV-3 viruses isolated from patients between 2000 and were fully sequenced. Five DENV2 and four DENV3 distinct lineages with different dynamics were identified. Each lineage was characterized by the presence of specific mutations with no evidence of recombination. In both DENV-2 and DENV-3 the lineages present prior to 2003 were replaced after that date by unrelated lineages. After 2003, DENV-2 lineages D2-3 and D2-4 cocirculated until 2007 when they were almost completely replaced by a lineage D2-5 which emerged from Conversely, all DENV-3 lineages remained, diversified and cocirculated with novel lineages emerging. Years 2006 and 2007 were marked by a high prevalence of DENV-3 and 2007 with a large dengue outbreak and a high proportion of patients with severe disease. Selective sweeps in DENV-1 and DENV-2 were linked to immunological escape to a predominately DENV-3-driven immunological response. The complex dynamic of dengue in Cambodia in the last ten years has been associated with a combination of stochastic climatic events, cocirculation, coevolution, adaptation to different vector populations, and with the human population immunological landscape.
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https://hal-riip.archives-ouvertes.fr/pasteur-00793267
Contributor : Philippe Buchy <>
Submitted on : Friday, February 22, 2013 - 3:10:42 AM
Last modification on : Tuesday, February 11, 2020 - 10:10:29 AM
Document(s) archivé(s) le : Sunday, April 2, 2017 - 4:03:38 AM
Contributor : Philippe Buchy <>
Submitted on : Friday, February 22, 2013 - 3:10:42 AM
Last modification on : Tuesday, February 11, 2020 - 10:10:29 AM
Document(s) archivé(s) le : Sunday, April 2, 2017 - 4:03:38 AM
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Identifiers
- HAL Id : pasteur-00793267, version 1
- DOI : 10.1016/j.meegid.2012.05.012
- PUBMED : 22677620
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Citation
Veasna Duong, Matthew R. Henn, Cameron Simmons, Chantha Ngan, Bunthin Y, et al.. Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters. Infection, Genetics and Evolution, Elsevier, 2012, pp.N/A. ⟨10.1016/j.meegid.2012.05.012⟩. ⟨pasteur-00793267⟩
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