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Human bocavirus amongst an all-ages population hospitalised with acute lower respiratory infections in Cambodia.

Abstract : BACKGROUND: Human bocavirus (HBoV) is a novel parvovirus that is associated with respiratory and gastrointestinal tract disease. OBJECTIVES: To investigate the prevalence and genetic diversity of HBoV amongst hospitalized patients with acute lower respiratory infection (ALRI) in Cambodia. STUDY DESIGN: Samples were collected from 2773 patients of all ages hospitalised with symptoms of ALRI between 2007 and 2009. All samples were screened by multiplex RT-PCR/PCR for 18 respiratory viruses. All samples positive for HBoV were sequenced and included in this study. RESULTS: Of the samples tested, 43 (1*5%) were positive for HBoV. The incidence of HBoV did not vary between the consecutive seasons investigated, and HBoV infections were detected year-round. The incidence of HBoV infection was highest in patients aged < 2 years, with pneumonia or bronchopneumonia the most common clinical diagnosis, regardless of age. A total of 19 patients (44%) were co-infected with HBoV and an additional respiratory pathogen. All isolates were classified as HBoV type 1 (HBoV-1). High conservation between Cambodian NP1 and V1V2 gene sequences was observed. CONCLUSIONS: Human bocavirus infection can result in serious illness, however is frequently detected in the context of viral co-infection. Specific studies are required to further understand the true pathogenesis of HBoV in the context of severe respiratory illness.
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Submitted on : Friday, April 5, 2013 - 3:49:39 AM
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Alicia Arnott, Sirenda Vong, Sareth Rith, Monica Naughtin, Sowath Ly, et al.. Human bocavirus amongst an all-ages population hospitalised with acute lower respiratory infections in Cambodia.. Influenza and Other Respiratory Viruses, Wiley Open Access, 2013, 7 (2), pp.201-10. ⟨10.1111/j.1750-2659.2012.00369.x⟩. ⟨pasteur-00808140⟩

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