A. Bharti, J. Nally, J. Ricaldi, M. Matthias, and M. Diaz, Leptospirosis: a zoonotic disease of global importance, The Lancet Infectious Diseases, vol.3, issue.12, pp.757-771, 2003.
DOI : 10.1016/S1473-3099(03)00830-2

A. Mcbride, D. Athanazio, M. Reis, and A. Ko, Leptospirosis, Current Opinion in Infectious Diseases, vol.18, issue.5, pp.376-386, 2005.
DOI : 10.1097/01.qco.0000178824.05715.2c

A. Spichler, A. Ko, E. Silva, D. Brito, T. Silva et al., Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy, Am J Trop Med Hyg, vol.77, pp.1111-1119, 2007.

D. Brett-major and R. Coldren, Antibiotics for leptospirosis, Cochrane Database Syst Rev, vol.2, p.8264, 2012.

M. Pound and D. May, Proposed mechanisms and preventative options of Jarisch-Herxheimer reactions, Journal of Clinical Pharmacy and Therapeutics, vol.48, issue.3, pp.291-295, 2005.
DOI : 10.1001/archderm.125.1.77

K. Herxheimer and D. Krause, Ueber eine bei Syphilitischen vorkommende Quecksilberreaktion, DMW - Deutsche Medizinische Wochenschrift, vol.28, issue.50, pp.895-897, 1902.
DOI : 10.1055/s-0028-1139096

J. Shenep, S. Feldman, and D. Thornton, Evaluation for Endotoxemia in Patients Receiving Penicillin Therapy for Secondary Syphilis, JAMA: The Journal of the American Medical Association, vol.256, issue.3, pp.388-390, 1986.
DOI : 10.1001/jama.1986.03380030090035

A. Maloy, R. Black, R. Segurola, and J. , Lyme Disease Complicated by the Jarisch-Herxheimer Reaction, The Journal of Emergency Medicine, vol.16, issue.3, pp.437-438, 1998.
DOI : 10.1016/S0736-4679(98)00011-0

M. Dworkin, D. Anderson, J. Schwan, T. Shoemaker, P. Banerjee et al., Tick???Borne Relapsing Fever in the Northwestern United States and Southwestern Canada, Clinical Infectious Diseases, vol.26, issue.1, pp.122-131, 1998.
DOI : 10.1086/516273

A. Bryceson, K. Cooper, D. Warrell, P. Perine, and E. Parry, Endotoxin, Clinical Science, vol.43, issue.3, pp.343-354, 1972.
DOI : 10.1042/cs0430343

D. Warrell, P. Perine, D. Krause, D. Bing, and S. Macdougal, Pathophysiology and Immunology of the Jarisch-Herxheimer-Like Reaction in Louse-Borne Relapsing Fever: Comparison of Tetracycline and Slow-Release Penicillin, Journal of Infectious Diseases, vol.147, issue.5, pp.898-909, 1983.
DOI : 10.1093/infdis/147.5.898

D. Fekade, K. Knox, K. Hussein, A. Melka, and D. Lalloo, Prevention of Jarisch???Herxheimer Reactions by Treatment with Antibodies against Tumor Necrosis Factor ??, New England Journal of Medicine, vol.335, issue.5, pp.311-315, 1996.
DOI : 10.1056/NEJM199608013350503

G. Cook and A. Zumla, Manson's Tropical diseases, 2008.

R. Guerrant, D. Walker, and P. Weller, Tropical Infectious Diseases, 2011.

G. Mandell, J. Bennett, and R. Dolin, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, p.3102, 2009.

S. Gorbach, J. Bartlett, and N. Blacklow, Infectious diseases: Lippincott Williams and Wilkins, 1469.

G. Watt, L. Padre, M. Tuazon, C. Calubaquib, and E. Santiago, PLACEBO-CONTROLLED TRIAL OF INTRAVENOUS PENICILLIN FOR SEVERE AND LATE LEPTOSPIROSIS, The Lancet, vol.331, issue.8583, pp.433-435, 1988.
DOI : 10.1016/S0140-6736(88)91230-5

D. Munnich and M. Lakatos, Treatment of leptospirosis with Semicillin, Ther Hung, vol.20, pp.152-155, 1972.

J. Friedland and D. Warrell, The Jarisch-Herxheimer Reaction in Leptospirosis: Possible Pathogenesis and Review, Clinical Infectious Diseases, vol.13, issue.2, pp.207-210, 1991.
DOI : 10.1093/clinids/13.2.207

K. Phimda, S. Hoontrakul, C. Suttinont, S. Chareonwat, and K. Losuwanaluk, Doxycycline versus Azithromycin for Treatment of Leptospirosis and Scrub Typhus, Antimicrobial Agents and Chemotherapy, vol.51, issue.9, pp.3259-3263, 2007.
DOI : 10.1128/AAC.00508-07

R. Markham, A. Slack, and G. J. , The Jarisch???Herxheimer reaction in a patient with leptospirosis: a foreseeable problem in managing spirochaete infections, The Medical Journal of Australia, vol.197, issue.5, pp.276-277, 2012.
DOI : 10.5694/mja11.11175

T. Hashimoto, S. Akata, J. Park, Y. Harada, and Y. Hirayama, High-resolution Computed Tomography Findings in a Case of Severe Leptospira Infection (Weil Disease) Complicated With Jarisch-Herxheimer Reaction, Journal of Thoracic Imaging, vol.27, issue.1, pp.24-26, 2012.
DOI : 10.1097/RTI.0b013e318231535b

K. Masuda, Y. Uehara, H. Ono, and K. Furukawa, [A case of severe leptospirosis infection (Weil's disease) in Tokyo], Kansenshogaku Zasshi, vol.84, pp.59-64, 2010.

P. Tattevin, S. Jaureguiberry, and C. Michelet, Meningitis as a Possible Feature of the Jarisch-Herxheimer Reaction in Leptospirosis, European Journal of Clinical Microbiology & Infectious Diseases, vol.22, issue.7, p.449, 2003.
DOI : 10.1007/s10096-003-0957-8

C. Emmanouilides, O. Kohn, and R. Garibaldi, Leptospirosis Complicated by a Jarisch-Herxheimer Reaction and Adult Respiratory Distress Syndrome: Case Report, Clinical Infectious Diseases, vol.18, issue.6, pp.1004-1006, 1994.
DOI : 10.1093/clinids/18.6.1004

L. Swiader, P. Disdier, F. Retornaz, F. Pauzier, and J. Harle, Jarisch- Herxheimer reaction in leptospirosis], Presse Med, vol.24, p.1753, 1995.

C. Lau and J. , Leptospirosis, American Samoa, Emerg Infect Dis [Internet], 2012.
DOI : 10.3201/eid1812.120429

URL : http://doi.org/10.3201/eid1812.120429

J. Crooks and W. Blair, L. Canicola Infection Treated by Penicillin, BMJ, vol.1, issue.4918, pp.885-887, 1955.
DOI : 10.1136/bmj.1.4918.885

M. Narita, S. Fujitani, D. Haake, and D. Paterson, Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan, Am J Trop Med Hyg, vol.73, pp.652-656, 2005.

C. Vaughan, C. Cronin, E. Walsh, and M. Whelton, The Jarisch-Herxheimer reaction in leptospirosis., Postgraduate Medical Journal, vol.70, issue.820, pp.118-121, 1994.
DOI : 10.1136/pgmj.70.820.118

C. Winearls, L. Chan, J. Coghlan, J. Ledingham, and D. Oliver, Acute renal failure due to leptospirosis: clinical features and outcome in six cases, Q J Med, vol.53, pp.487-495, 1984.

J. Mackay-dick and J. Robinson, Penicillin in the treatment of 84 cases of leptospirosis in Malaya, J R Army Med Corps, vol.103, pp.186-197, 1957.

Y. Suputtamongkol, K. Niwattayakul, C. Suttinont, K. Losuwanaluk, and R. Limpaiboon, An Open, Randomized, Controlled Trial of Penicillin, Doxycycline, and Cefotaxime for Patients with Severe Leptospirosis, Clinical Infectious Diseases, vol.39, issue.10, pp.1417-1424, 2004.
DOI : 10.1086/425001

T. Panaphut, S. Domrongkitchaiporn, A. Vibhagool, B. Thinkamrop, and W. Susaengrat, Ceftriaxone Compared with Sodium Penicillin G for Treatment of Severe Leptospirosis, Clinical Infectious Diseases, vol.36, issue.12, pp.1507-1513, 2003.
DOI : 10.1086/375226

E. Costa, A. Lopes, E. Sacramento, Y. Costa, and E. Matos, Penicillin at the late stage of leptospirosis: a randomized controlled trial, Revista do Instituto de Medicina Tropical de S??o Paulo, vol.45, issue.3, pp.141-145, 2003.
DOI : 10.1590/S0036-46652003000300005

C. Edwards, G. Nicholson, T. Hassell, C. Everard, and J. Callender, Penicillin therapy in icteric leptospirosis, Am J Trop Med Hyg, vol.39, pp.388-390, 1988.

J. Mcclain, W. Ballou, S. Harrison, and D. Steinweg, Doxycycline Therapy for Leptospirosis, Annals of Internal Medicine, vol.100, issue.5, pp.696-698, 1984.
DOI : 10.7326/0003-4819-100-5-696

G. Watt, L. Padre, M. Tuazon, and C. Calubaquib, Limulus Lysate Positivity and Herxheimer-Iike Reactions in Leptospirosis: A Placebo-Controlled Study, Journal of Infectious Diseases, vol.162, issue.2, pp.564-567, 1990.
DOI : 10.1093/infdis/162.2.564

R. Russell, TREATMENT OF LEPTOSPIROSIS WITH OXYTETRACYCLINE, The Lancet, vol.272, issue.7057, pp.1143-1145, 1958.
DOI : 10.1016/S0140-6736(58)92405-X

R. Doherty, A clinical study of leptospirosis in North Queensland, Australas Ann Med, vol.4, pp.53-63, 1955.

DOI : 10.1016/S0140-6736(56)91853-0

H. Hall, J. Hightower, D. Rivera, R. Byrne, R. Smadel et al., Evaluation of antibiotic therapy in human leptospirosis, Ann Intern Med, vol.35, pp.981-998, 1951.

P. Marotto, M. Marotto, D. Santos, T. Souza, and A. Seguro, Outcome of leptospirosis in children, Am J Trop Med Hyg, vol.56, pp.307-310, 1997.

E. Daher and C. Nogueira, Evaluation of penicillin therapy in patients with leptospirosis and acute renal failure, Revista do Instituto de Medicina Tropical de S??o Paulo, vol.42, issue.6, pp.327-332, 2000.
DOI : 10.1590/S0036-46652000000600005

H. Dupont, D. Dupont-perdrizet, J. Perie, S. Zehner-hansen, and B. Jarrige, Leptospirosis: Prognostic Factors Associated with Mortality, Clinical Infectious Diseases, vol.25, issue.3, pp.720-724, 1997.
DOI : 10.1086/513767

A. Spichler, P. Vilaca, D. Athanazio, J. Albuquerque, and M. Buzzar, Predictors of lethality in severe leptospirosis in urban Brazil, Am J Trop Med Hyg, vol.79, pp.911-914, 2008.