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CD8(+) T cells in leishmania infections: friends or foes?

Abstract : Host protection against several intracellular pathogens requires the induction of CD8(+) T cell responses. CD8(+) T cells are potent effector cells that can produce high amounts of pro-inflammatory cytokines and kill infected target cells efficiently. However, a protective role for CD8(+) T cells during Leishmania infections is still controversial and largely depends on the infection model. In this review, we discuss the role of CD8(+) T cells during various types of Leishmania infections, following vaccination, and as potential immunotherapeutic targets.
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Contributor : Charles M. Dozois <>
Submitted on : Wednesday, April 17, 2013 - 10:27:58 PM
Last modification on : Wednesday, October 14, 2020 - 3:58:38 AM

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Simona Stäger, Sima Rafati. CD8(+) T cells in leishmania infections: friends or foes?. Frontiers in Immunology, Frontiers, 2012, 3, pp.5. ⟨10.3389/fimmu.2012.00005⟩. ⟨pasteur-00814922⟩

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