Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Leishmania promastigotes: building a safe niche within macrophages.

Neda Morandini 1 Albert Descoteaux 1, * 
* Corresponding author
Abstract : Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole.
Document type :
Journal articles
Complete list of metadata

https://hal-riip.archives-ouvertes.fr/pasteur-00818346
Contributor : Charles M. Dozois Connect in order to contact the contributor
Submitted on : Friday, April 26, 2013 - 4:22:39 PM
Last modification on : Tuesday, October 20, 2020 - 9:50:05 AM

Links full text

Identifiers

Collections

Citation

Neda Morandini, Albert Descoteaux. Leishmania promastigotes: building a safe niche within macrophages.. Frontiers in Cellular and Infection Microbiology, Frontiers, 2012, 2 (2), pp.121. ⟨10.3389/fcimb.2012.00121⟩. ⟨pasteur-00818346⟩

Share

Metrics

Record views

16