Leishmania promastigotes: building a safe niche within macrophages.

Abstract : Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole.
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Submitted on : Friday, April 26, 2013 - 4:22:39 PM
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Neda Morandini, Albert Descoteaux. Leishmania promastigotes: building a safe niche within macrophages.. Front Cell Infect Microbiol, 2012, 2 (2), pp.121. ⟨10.3389/fcimb.2012.00121⟩. ⟨pasteur-00818346⟩

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