Marginal zone B cells regulate antigen-specific T cell responses during infection.

Rashmi Bankoti (1) , Kshitiz Gupta (2) , Andre Levchenko (2, 3) , Simona Stäger (1, 4)

1 Department of Molecular and Comparative Pathobiology
2 DBE - Department of Biomedical Engineering [Baltimore]
3 ICM - Institute for Computational Medicine
4 INRS-IAF - Institut Armand Frappier

Marginal zone B cells (MZB) participate in the early immune response to several pathogens. In this study, we show that in μMT mice infected with Leishmania donovani, CD8 T cells displayed a greater cytotoxic potential and generated more effector memory cells compared with infected wild type mice. The frequency of parasite-specific, IFN-γ(+) CD4 T cells was also increased in μMT mice. B cells were able to capture parasites, which was associated with upregulation of surface IgM and MyD88-dependent IL-10 production. Moreover, MZB presented parasite Ags to CD4 T cells in vitro. Depletion of MZB also enhanced T cell responses and led to a decrease in the parasite burden but did not alter the generation of effector memory T cells. Thus, MZB appear to suppress protective T cell responses during the early stages of L. donovani infection.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Rashmi Bankoti, Kshitiz Gupta, Andre Levchenko, Simona Stäger. Marginal zone B cells regulate antigen-specific T cell responses during infection.. Journal of Immunology, 2012, 188 (8), pp.3961-71. ⟨10.4049/jimmunol.1102880⟩. ⟨pasteur-00819065⟩