Marginal zone B cells regulate antigen-specific T cell responses during infection. - Archive ouverte HAL Access content directly
Journal Articles Journal of Immunology Year : 2012

Marginal zone B cells regulate antigen-specific T cell responses during infection.

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Abstract

Marginal zone B cells (MZB) participate in the early immune response to several pathogens. In this study, we show that in μMT mice infected with Leishmania donovani, CD8 T cells displayed a greater cytotoxic potential and generated more effector memory cells compared with infected wild type mice. The frequency of parasite-specific, IFN-γ(+) CD4 T cells was also increased in μMT mice. B cells were able to capture parasites, which was associated with upregulation of surface IgM and MyD88-dependent IL-10 production. Moreover, MZB presented parasite Ags to CD4 T cells in vitro. Depletion of MZB also enhanced T cell responses and led to a decrease in the parasite burden but did not alter the generation of effector memory T cells. Thus, MZB appear to suppress protective T cell responses during the early stages of L. donovani infection.

Dates and versions

pasteur-00819065 , version 1 (30-04-2013)

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Rashmi Bankoti, Kshitiz Gupta, Andre Levchenko, Simona Stäger. Marginal zone B cells regulate antigen-specific T cell responses during infection.. Journal of Immunology, 2012, 188 (8), pp.3961-71. ⟨10.4049/jimmunol.1102880⟩. ⟨pasteur-00819065⟩

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