Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Occupational exposure to silica and lung cancer: pooled analysis of two case-control studies in Montreal, Canada.

Abstract : BACKGROUND: Respirable crystalline silica is a highly prevalent occupational exposure and a recognized lung carcinogen. Most previous studies have focused on selected high-exposure occupational groups. This study examines the relationship between occupational exposure to silica and lung cancer in an occupationally diverse male population. METHODS: Two large population-based case-control studies of lung cancer were conducted in Montreal, one in 1979-1986 (857 cases, 533 population controls, 1,349 cancer controls) and the second in 1996-2001 (738 cases and 899 controls). Interviews provided descriptive lifetime job histories, smoking histories, and other information. Industrial hygienists translated job histories into histories of exposure to a host of occupational substances, including silica. Relative risk was estimated, adjusting for several potential confounders, including smoking. RESULTS: The odds ratio for substantial exposure to silica was 1.67 (95% confidence interval, 1.21-2.31) and for any exposure was 1.31 (95% confidence interval, 1.08-1.59). Joint effects between silica and smoking were between additive and multiplicative, perhaps closer to the latter. In this population, it is estimated that approximately 3% of lung cancers were attributable to substantial silica exposure. CONCLUSIONS: The carcinogenicity of inhaled crystalline silica was observed in a population with a wide variety of exposure circumstances. IMPACT: The finding of carcinogenicity across a wide range of occupations complements prior studies of specific high-exposure occupations. This suggests that the burden of cancer induced by silica may be much greater than previously thought.
Document type :
Journal articles
Complete list of metadata

https://hal-riip.archives-ouvertes.fr/pasteur-00819525
Contributor : Charles M. Dozois Connect in order to contact the contributor
Submitted on : Wednesday, May 1, 2013 - 8:33:51 PM
Last modification on : Monday, July 20, 2020 - 12:33:15 PM

Identifiers

Collections

Citation

Stephen Vida, Javier Pintos, Marie-Elise Parent, Jerome Lavoué, Jack Siemiatycki. Occupational exposure to silica and lung cancer: pooled analysis of two case-control studies in Montreal, Canada.. Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2010, 19 (6), pp.1602-11. ⟨10.1158/1055-9965.EPI-10-0015⟩. ⟨pasteur-00819525⟩

Share

Metrics

Record views

23