Viral infectivity and intracellular distribution of matrix (M) protein of canine distemper virus are affected by actin filaments. - Archive ouverte HAL Access content directly
Journal Articles Archives of Virology Year : 2010

Viral infectivity and intracellular distribution of matrix (M) protein of canine distemper virus are affected by actin filaments.

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Abstract

To investigate the role of cytoskeletal components in canine distemper virus (CDV) replication, various agents were used that interfere with turnover of actin filaments and microtubules. Only inhibition of actin filaments significantly reduced viral infectivity. Analysis of the intracellular localization of the viral matrix (M) protein revealed that it aligned along actin filaments. Treatment with actin filament-disrupting drugs led to a marked intracellular redistribution of M protein during infection as well as transfection. In contrast, the localization of the CDV fusion (F) protein was not significantly changed during transfection. Thus, a M protein-actin filament interaction appears to be important for generation of infectious CDV.

Dates and versions

pasteur-00819561 , version 1 (01-05-2013)

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F. Klauschies, T. Gützkow, S. Hinkelmann, V. von Messling, B. Vaske, et al.. Viral infectivity and intracellular distribution of matrix (M) protein of canine distemper virus are affected by actin filaments.. Archives of Virology, 2010, 155 (9), pp.1503-8. ⟨10.1007/s00705-010-0737-6⟩. ⟨pasteur-00819561⟩

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