Involvement of tyrosine phosphatase CD45 in apoptosis.

Abstract : CD45 is a transmembrane molecule with phosphatase activity expressed in all nucleated haematopoietic cells and plays a major role in immune cells. It is a protein tyrosine phosphatase that is essential for antigen-receptor-mediated signal transduction by regulating Src family members that initiate TCR signaling. CD45 is being attributed a new emerging role as an apoptosis regulator. Cross-linking of the extracellular portion of the CD45 by monoclonal antibodies and by galectin-1, can induce apoptosis in T and B cells. Interestingly, this phosphatase has also been involved in nuclear apoptosis induced by mitochondrial perturbing agents. Furthermore, it is involved in apoptosis induced by HIV-1. CD45 defect is implicated in various diseases such as severe-combined immunodeficiency disease (SCID), acquired immunodeficiency syndrome (AIDS), lymphoma and multiple myelomas. The understanding of the mechanisms by which CD45 regulates apoptosis would be very useful in disease treatment.
Document type :
Journal articles
Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-00819587
Contributor : Charles M. Dozois <>
Submitted on : Wednesday, May 1, 2013 - 11:01:32 PM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM

Links full text

Identifiers

Collections

Citation

Geneviève Dupéré-Minier, Philippe Desharnais, Jacques Bernier. Involvement of tyrosine phosphatase CD45 in apoptosis.. Apoptosis, Springer Verlag, 2010, 15 (1), pp.1-13. ⟨10.1007/s10495-009-0413-z⟩. ⟨pasteur-00819587⟩

Share

Metrics

Record views

99