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Lymphoma cells contribute to the augmentation of plasma sL-selectins in the serum of lymphoma-bearing mice.

Abstract : Like many integral membrane glycoproteins, the extracellular domain of L-selectin undergoes rapid shedding, which occurs on both resting and activated host leucocytes. Incubating normal or transformed leukocytes with phorbol esters can also artificially induce shedding of L-selectin, providing multiple possibilities for the source of soluble forms of L-selectin found in the serum of patients with hematological malignancies. Here, using genetically engineered L-selectin-deficient mouse models, we have measured the release of soluble circulating forms of L-selectin in the serum of lymphoma-bearing mice. We found that L-selectin-deficient lymphoma cells could not induce an elevation of circulating soluble forms of L-selectin in normal mice, as compared to lymphoma cells expressing L-selectin. Moreover, soluble forms of L-selectin were detected in the serum in mice bearing lymphoma induced by injection of T lymphoma cells expressing L-selectins. Interestingly, we also found that lymphoma cells that are unable to shed L-selectin in vitro following exposure to phorbol ester can generate soluble forms of serum L-selectin in vivo. Taken together, these results indicate that lymphoma cells are the major contributors to levels of soluble forms of L-selectins in lymphoma-bearing mice.
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https://hal-riip.archives-ouvertes.fr/pasteur-00819612
Contributor : Charles M. Dozois <>
Submitted on : Wednesday, May 1, 2013 - 11:58:31 PM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM

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Caroline Aubé, Simon D Bélanger, Yves St-Pierre. Lymphoma cells contribute to the augmentation of plasma sL-selectins in the serum of lymphoma-bearing mice.. Leukemia & lymphoma, Taylor & Francis, 2010, 51 (1), pp.125-31. ⟨10.3109/10428190903421177⟩. ⟨pasteur-00819612⟩

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