The outcome of cross-priming during virus infection is not directly linked to the ability of the antigen to be cross-presented. - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue European Journal of Immunology Année : 2010

The outcome of cross-priming during virus infection is not directly linked to the ability of the antigen to be cross-presented.

Résumé

The initiation of CD8(+) T cell (CTL) immune responses can occur via cross-priming. Recent data suggested a relationship between cross-presentation and immunodominance of epitope-specific T cells. To test this association, we evaluated the efficacy of cross-presentation for several virus epitopes in vitro and examined if this can be extrapolated in vivo. Employing lymphocytic choriomeningitis virus (LCMV), we demonstrate that the cross-presentation and cross-priming of LCMV antigens were dominated by NP396, but not NP205 when analyzing the LCMV-NP. Although with LCMV-GP, cross-presentation was dominated by GP276, and cross-priming was dominated by GP33. Importantly, although NP396 was significantly more efficient than GP33 in cross-presentation, cross-priming of their specific CTL was comparable. In a subsequent virus challenge after cross-priming, GP33-specific CTL dominated the response. Accordingly, based on our data, the ability of viral epitopes to be cross-presented in vitro does not entirely reflect what would occur in cross-priming. Thus, weak cross-presenting antigens may still cross-prime an efficient CTL response depending on other in vivo elements such as the naïve T-cell precursor frequencies.

Dates et versions

pasteur-00819623 , version 1 (02-05-2013)

Identifiants

Citer

Attiya Alatery, Esther Tarrab, Alain Lamarre, Sameh Basta. The outcome of cross-priming during virus infection is not directly linked to the ability of the antigen to be cross-presented.. European Journal of Immunology, 2010, 40 (8), pp.2190-9. ⟨10.1002/eji.200939973⟩. ⟨pasteur-00819623⟩

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