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Expression of placental serotonin transporter and 5-HT 2A receptor in normal and gestational diabetes mellitus pregnancies.

Abstract : Recent studies reveal that serotonin (5-hydroxytryptamine, 5-HT) might play a role in the aetiology of gestational diabetes mellitus (GDM). The involvement of the serotonin transporter (SERT) and 5-HT(2A) receptor (5-HT(2A)R) in diabetes has also been suggested. However, placental SERT and 5-HT(2A)R have never been studied in GDM-complicated pregnancies. The aim of this study was to investigate the effect of GDM on the expression of both placental SERT and 5-HT(2A)R. First, immunohistochemical analysis demonstrated the presence of SERT and 5-HT(2A)R proteins in the villous trophoblast and the fetal capillary endothelium of normal term placental tissue. Protein and mRNA expression of SERT and 5-HT(2A)R in the villous cytotrophoblastic and syncytiotrophoblastic cells was further confirmed in primary culture. A significantly (P < 0.05) decreased expression of SERT mRNA (56.3%) and protein (79.7%), and 5-HT(2A)R mRNA (79.1%) and protein (29.1%) was observed in placental tissues from GDM compared with non-GDM pregnancies. These data suggest that SERT and 5-HT(2A)R might be implicated in the aetiology of GDM. Moreover, the presence of SERT and 5-HT(2A)R in villous trophoblastic cells argues in favour of an important role of serotonin in human placental function.
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Submitted on : Thursday, May 2, 2013 - 3:30:32 AM
Last modification on : Friday, March 27, 2020 - 3:18:03 PM

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Mélanie Viau, Julie Lafond, Cathy Vaillancourt. Expression of placental serotonin transporter and 5-HT 2A receptor in normal and gestational diabetes mellitus pregnancies.. Reproductive BioMedicine Online, Elsevier, 2009, 19 (2), pp.207-15. ⟨10.1016/S1472-6483(10)60074-0⟩. ⟨pasteur-00819631⟩

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