A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.

Ronan Nicolas Rouxel (1) , Nicholas Svitek (1) , Veronika von Messling (1)

1 INRS-IAF - Institut Armand Frappier

CDV infects a broad range of carnivores, and over the past decades it has caused outbreaks in a variety of wild carnivore populations. Since the currently available live-attenuated vaccine is not sufficiently safe in these highly susceptible species, we produced a chimeric virus combining the replication complex of the measles Moraten vaccine strain with the envelope of a recent CDV wild type isolate. The resulting virus did not cause disease or immunosuppression in ferrets and conferred protection from challenge with a lethal wild type strain, demonstrating its potential value for wildlife conservation efforts.

Domaines: Maladies infectieuses

Ronan Nicolas Rouxel, Nicholas Svitek, Veronika von Messling. A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.. Vaccine, 2009, 27 (36), pp.4961-6. ⟨10.1016/j.vaccine.2009.05.096⟩. ⟨pasteur-00819649⟩