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Journal Articles Vaccine Year : 2009

A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.

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Abstract

CDV infects a broad range of carnivores, and over the past decades it has caused outbreaks in a variety of wild carnivore populations. Since the currently available live-attenuated vaccine is not sufficiently safe in these highly susceptible species, we produced a chimeric virus combining the replication complex of the measles Moraten vaccine strain with the envelope of a recent CDV wild type isolate. The resulting virus did not cause disease or immunosuppression in ferrets and conferred protection from challenge with a lethal wild type strain, demonstrating its potential value for wildlife conservation efforts.
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pasteur-00819649 , version 1 (02-05-2013)

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Ronan Nicolas Rouxel, Nicholas Svitek, Veronika von Messling. A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.. Vaccine, 2009, 27 (36), pp.4961-6. ⟨10.1016/j.vaccine.2009.05.096⟩. ⟨pasteur-00819649⟩

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