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A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.

Abstract : CDV infects a broad range of carnivores, and over the past decades it has caused outbreaks in a variety of wild carnivore populations. Since the currently available live-attenuated vaccine is not sufficiently safe in these highly susceptible species, we produced a chimeric virus combining the replication complex of the measles Moraten vaccine strain with the envelope of a recent CDV wild type isolate. The resulting virus did not cause disease or immunosuppression in ferrets and conferred protection from challenge with a lethal wild type strain, demonstrating its potential value for wildlife conservation efforts.
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https://hal-riip.archives-ouvertes.fr/pasteur-00819649
Contributor : Charles M. Dozois <>
Submitted on : Thursday, May 2, 2013 - 4:22:27 AM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM

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Ronan Nicolas Rouxel, Nicholas Svitek, Veronika von Messling. A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.. Vaccine, Elsevier, 2009, 27 (36), pp.4961-6. ⟨10.1016/j.vaccine.2009.05.096⟩. ⟨pasteur-00819649⟩

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