Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada.

Javier Pintos; Marie-Elise Parent; Marie-Claude Rousseau; Bruce W Case; Jack Siemiatycki

Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada.

Javier Pintos ^{1, *} Marie-Elise Parent ¹ Marie-Claude Rousseau ¹ Bruce W Case ² Jack Siemiatycki ³

* Corresponding author

1 INRS-IAF - Institut Armand Frappier

2 CRCHUM - Hospital Research Centre

3 CRCHUM - University of Montreal Hospital Research Center

Abstract : OBJECTIVE: To examine the effects of occupational asbestos and man-made vitreous fibers (MMVF) on the risk of lung cancer in two population-based case-control studies entailing exposure at lower levels than in historic cohort studies. METHODOLOGY: Study I (1979 to 1986) comprised 857 cases and 1066 population and cancer controls. Study II (1996 to 2001) comprised 858 cases and 1295 population controls. A detailed job history was obtained to evaluate lifetime occupational exposure to 294 agents, including asbestos and MMVF. RESULTS: We found increased risks for substantial exposure to asbestos (odds ratio = 1.78; 95% confidence interval: 0.94 to 3.36). The corresponding odds ratio for substantial exposure to MMVF was 1.10 (95% confidence interval: 0.37 to 3.22). DISCUSSION: Low and moderate levels of exposure to asbestos, as encountered in this population, were associated with some excess risk of lung cancer. Results for MMVF were inconclusive.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology / Infectious diseases

Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-00819971
Contributor : Charles M. Dozois <>
Submitted on : Thursday, May 2, 2013 - 9:27:34 PM
Last modification on : Friday, April 26, 2019 - 4:22:03 PM

Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada.

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Occupational exposure to asbestos and man-made vitreous fibers, and risk of lung cancer: evidence from two case-control studies in Montreal, Canada.

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