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Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis.

Vera C B Cainelli Gebara 1, * Luciana Risoléo 1 Alexandre P Y Lopes 1 Vera R F Ferreira 1 Wagner Quintilio 2 François Lépine 3 Wilmar D Silva 4 Isaías Raw 1
* Corresponding author
1 Centro de Biotecnologia [Sao Paulo]
2 Serviço de Controle de Qualidade
3 INRS-IAF - Institut Armand Frappier
4 Centro de Biociencias e Biotecnologia
Abstract : A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal alpha-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge. IgG1 and IgG2a were stimulated suggesting that the immune response could be modulated to produce Th1 or Th2.
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https://hal-riip.archives-ouvertes.fr/pasteur-00819998
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Submitted on : Thursday, May 2, 2013 - 10:24:14 PM
Last modification on : Tuesday, August 11, 2020 - 11:38:09 AM

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Vera C B Cainelli Gebara, Luciana Risoléo, Alexandre P Y Lopes, Vera R F Ferreira, Wagner Quintilio, et al.. Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis.. Vaccine, Elsevier, 2007, 25 (4), pp.621-9. ⟨10.1016/j.vaccine.2006.08.033⟩. ⟨pasteur-00819998⟩

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