A silent composite hemoglobinopathy characterized by gene sequencing.

A. Zorai** (1) , I. Moumni** (2) , I. Benmansour (2) , D. Chaouachi (2) , A. Ghanem (3) , S. Abbes (2, 3)

1 Laboratory of Molecular and Cellular Hematology
2 LR11IPT07 - Laboratoire d'hématologie moléculaire et cellulaire
3 Département de biochimie

We report the case of a 35-year-old Tunisian women with a chronic anemia non investigated for a long time. Laboratory analysis using advanced technology of DNA sequencing revealed a compound heterozygote for Hb O Arab and cd 39 beta degrees-thalassemia. It's the first time that such a genotype has been characterized by gene sequencing.

Keywords: Chronic anemia; Hb O-Arab/ β°-thalassemia association; DNA sequencing

Domains: Life Sciences [q-bio]; Human health and pathology; Hematology; Life Sciences [q-bio]; Biochemistry, Molecular Biology

A. Zorai**, I. Moumni**, I. Benmansour, D. Chaouachi, A. Ghanem, et al.. A silent composite hemoglobinopathy characterized by gene sequencing.. Archives de l'Institut Pasteur de Tunis, 2011, 88 (1-4), pp.67-70. ⟨pasteur-00821691⟩